Gene
pcdh8
- ID
- ZDB-GENE-980526-242
- Name
- protocadherin 8
- Symbol
- pcdh8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in dendrite; postsynaptic membrane; and presynaptic membrane. Predicted to be active in plasma membrane and synapse. Is expressed in several structures, including germ ring; margin; mesoderm; presumptive mesoderm; and retina. Orthologous to human PCDH8 (protocadherin 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 100 figures from 79 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu375 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Skouloudaki et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin, N-terminal | Protocadherin/Cadherin-related Cell Adhesion |
---|---|---|---|---|---|---|---|
UniProtKB:O93508 | InterPro | 950 | |||||
UniProtKB:A0A8M1P773 | InterPro | 950 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- da Silva Pescador, G., Baia Amaral, D., Varberg, J.M., Zhang, Y., Hao, Y., Florens, L., Bazzini, A.A. (2024) Protein profiling of zebrafish embryos unmasks regulatory layers during early embryogenesis. Cell Reports. 43:114769114769
- Labbaf, Z., Petratou, K., Ermlich, L., Backer, W., Tarbashevich, K., Reichman-Fried, M., Luschnig, S., Schulte-Merker, S., Raz, E. (2022) A robust and tunable system for targeted cell ablation in developing embryos. Developmental Cell. 57(16):2026-2040.e5
- Liu, M., Zou, X., Fu, M., Bai, X., Zhao, Y., Chen, X., Wang, X., Wang, P., Huang, S. (2022) Mild cold stress specifically disturbs clustering movement of DFCs and sequential organ left-right patterning in zebrafish. Frontiers in cell and developmental biology. 10:952844
- Saraswathy, V.M., Kurup, A.J., Sharma, P., Polès, S., Poulain, M., Fürthauer, M. (2022) The E3 Ubiquitin Ligase Mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation. eLIFE. 11:
- Truszkowski, L., Batur, D., Long, H., Tarbashevich, K., Vos, B.E., Trappmann, B., Raz, E. (2022) Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo. Development (Cambridge, England). 150(2):
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Fulton, T., Trivedi, V., Attardi, A., Anlas, K., Dingare, C., Arias, A.M., Steventon, B. (2020) Axis Specification in Zebrafish Is Robust to Cell Mixing and Reveals a Regulation of Pattern Formation by Morphogenesis. Current biology : CB. 30(15):2984-2994.e3
- Gross-Thebing, S., Truszkowski, L., Tenbrinck, D., Sánchez-Iranzo, H., Camelo, C., Westerich, K.J., Singh, A., Maier, P., Prengel, J., Lange, P., Hüwel, J., Gaede, F., Sasse, R., Vos, B.E., Betz, T., Matis, M., Prevedel, R., Luschnig, S., Diz-Muñoz, A., Burger, M., Raz, E. (2020) Using migrating cells as probes to illuminate features in live embryonic tissues. Science advances. 6(49):
- Osborn, D.P.S., Li, K., Cutty, S.J., Nelson, A.C., Wardle, F.C., Hinits, Y., Hughes, S.M. (2020) Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Development (Cambridge, England). 147(8):
- Prajapati, R.S., Mitter, R., Vezzaro, A., Ish-Horowicz, D. (2020) Greb1 is required for axial elongation and segmentation in vertebrate embryos. Biology Open. 9(2):
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