Gene
twist2
- ID
- ZDB-GENE-980526-235
- Name
- twist2
- Symbol
- twist2 Nomenclature History
- Previous Names
-
- dermo1
- zgc:101904 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation. Is expressed in several structures, including cardiovascular system; dermis; mesoderm; notochord; and tail bud. Used to study ablepharon macrostomia syndrome. Human ortholog(s) of this gene implicated in Barber-Say syndrome and ablepharon macrostomia syndrome. Orthologous to human TWIST2 (twist family bHLH transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101904 (19 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-twist2 | (4) | |
CRISPR2-twist2 | (5) | |
CRISPR3-twist2 | Zhang et al., 2017 | |
CRISPR4-twist2 | Bai et al., 2020 | |
MO1-twist2 | N/A | Yang et al., 2011 |
MO2-twist2 | N/A | Zhao et al., 2020 |
1 - 6 of 6
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
ablepharon macrostomia syndrome | Alliance | Ablepharon-macrostomia syndrome | 200110 |
Barber-Say syndrome | Alliance | Barber-Say syndrome | 209885 |
Focal facial dermal dysplasia 3, Setleis type | 227260 |
1 - 3 of 3
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
ablepharon macrostomia syndrome | twist2zf3421/zf3421 (AB) | standard conditions | Zhao et al., 2020 |
1 - 1 of 1
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
Domain | IPR047093 | Twist-related protein 1, basic helix-loop-helix domain |
Family | IPR050283 | E-box Binding Transcriptional Regulators |
Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
1 - 4 of 4
Domain Details Per Protein
Protein | Additional Resources | Length | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Twist-related protein 1, basic helix-loop-helix domain |
---|---|---|---|---|---|---|
UniProtKB:Q5XJI8 | InterPro | 163 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
twist2-201
(1)
|
Ensembl | 1,227 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-282H7 | ZFIN Curated Data | |
Encodes | cDNA | MGC:101904 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001005956 (1) | 1051 nt | ||
Genomic | GenBank:CU929427 (2) | 58358 nt | ||
Polypeptide | UniProtKB:Q5XJI8 (1) | 163 aa |
- Zheng, S., Liu, Y., Xia, X., Xiao, J., Ma, H., Yuan, X., Zhang, Y., Chen, Z., Peng, G., Li, W., Fei, J.F., Liu, Y. (2025) Sequence Context-Agnostic TadA-Derived Cytosine Base Editors for Genome-Wide Editing in Zebrafish. Advanced science (Weinheim, Baden-Wurttemberg, Germany). :e2411478e2411478
- Zhang, Y., Liu, Y., Qin, W., Zheng, S., Xiao, J., Xia, X., Yuan, X., Zeng, J., Shi, Y., Zhang, Y., Ma, H., Varshney, G.K., Fei, J.F., Liu, Y. (2024) Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish. Nature communications. 15:95269526
- Kamimoto, K., Stringa, B., Hoffmann, C.M., Jindal, K., Solnica-Krezel, L., Morris, S.A. (2023) Dissecting cell identity via network inference and in silico gene perturbation. Nature. 614(7949):742-751
- Tang, W.J., Watson, C.J., Olmstead, T., Allan, C.H., Kwon, R.Y. (2022) Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration. iScience. 25:103784
- Jacob, T., Chakravarty, A., Panchal, A., Patil, M., Ghodadra, G., Sudhakaran, J., Nuesslein-Volhard, C. (2021) Zebrafish twist2/dermo1 regulates scale shape and scale organization during skin development and regeneration. Cells & development. 166:203684
- Bai, H., Liu, L., An, K., Lu, X., Harrison, M., Zhao, Y., Yan, R., Lu, Z., Li, S., Lin, S., Liang, F., Qin, W. (2020) CRISPR/Cas9-mediated precise genome modification by a long ssDNA template in zebrafish. BMC Genomics. 21:67
- Carrington, B., Weinstein, R.N., Sood, R. (2020) BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish. Cells. 9(7):
- Zhao, Y., Louie, K.W., Tingle, C.F., Sha, C., Heisel, C.J., Unsworth, S.P., Kish, P.E., Kahana, A. (2020) Twist3 is required for dedifferentiation during extraocular muscle regeneration in adult zebrafish. PLoS One. 15:e0231963
- Zhao, Y., Shang, D., Ying, R., Cheng, H., Zhou, R. (2020) An optimized base editor with efficient C-to-T base editing in zebrafish. BMC Biology. 18:190
- Ma, R.C., Jacobs, C.T., Sharma, P., Kocha, K.M., Huang, P. (2018) Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish. PLoS Genetics. 14:e1007775
1 - 10 of 40
Show