Gene

twist2

ID
ZDB-GENE-980526-235
Name
twist2
Symbol
twist2 Nomenclature History
Previous Names
  • dermo1
  • zgc:101904 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation. Is expressed in several structures, including cardiovascular system; dermis; mesoderm; notochord; and tail bud. Used to study ablepharon macrostomia syndrome. Human ortholog(s) of this gene implicated in Barber-Say syndrome and ablepharon macrostomia syndrome. Orthologous to human TWIST2 (twist family bHLH transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
32 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
zf2114Allele with one point mutationExon 1MissenseCRISPR
zf2115Allele with one MNVExon 1UnknownCRISPR
zf3421Allele with one point mutationExon 1MissenseCRISPR
zf3440Allele with one point mutationExon 1UnknownENU
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Sequence Targeting Reagents
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Human Disease
Associated With twist2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ablepharon macrostomia syndrome Alliance Ablepharon-macrostomia syndrome 200110
Barber-Say syndrome Alliance Barber-Say syndrome 209885
Focal facial dermal dysplasia 3, Setleis type 227260
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Associated With twist2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR047093 Twist-related protein 1, basic helix-loop-helix domain
Family IPR050283 E-box Binding Transcriptional Regulators
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length E-box Binding Transcriptional Regulators Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Twist-related protein 1, basic helix-loop-helix domain
UniProtKB:Q5XJI8 InterPro 163
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 9
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA twist2-201 (1) Ensembl 1,227 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-282H7ZFIN Curated Data
EncodescDNAMGC:101904ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTWIST22
Amino acid sequence comparison (4)
Conserved genome location (synteny) (3)
MouseTwist21
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
Citations
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