Gene
dlx2b
- ID
- ZDB-GENE-980526-18
- Name
- distal-less homeobox 2b
- Symbol
- dlx2b Nomenclature History
- Previous Names
-
- dlx5
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; embryonic skeletal system development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including dental epithelium; dental mesenchyme; forebrain; parasphenoid; and splanchnocranium. Orthologous to human DLX2 (distal-less homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 51 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu649 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
bo2Tg | Transgenic insertion | Unknown | Unknown | DNA | |
bo3Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la013621Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la021112Tg | Transgenic insertion | Unknown | Unknown | DNA | |
zko590a | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Distal-less homeobox transcription factors | Distal-less-like homeobox protein, N-terminal domain | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q98876 | InterPro | 276 | |||||||
UniProtKB:A4IG28 | InterPro | 276 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(dlx2b:GFP) |
|
| 2 | (3) | |
Tg(dlx2b-actb2:EGFP,myl7:GFP) |
| 1 | Zebrafish Nomenclature Committee | ||
Tg(dlx2b:EGFP) |
|
| 1 | (8) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-18J14 | ZFIN Curated Data | |
Encodes | EST | eu649 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:162123 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131297 (1) | 1526 nt | ||
Genomic | GenBank:BX548015 (1) | 255582 nt | ||
Polypeptide | UniProtKB:A4IG28 (1) | 276 aa |
- Benard, E.L., Küçükaylak, I., Hatzold, J., Berendes, K.U.W., Carney, T.J., Beleggia, F., Hammerschmidt, M. (2023) wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(6):566-592
- Jackson, A., Lin, S.J., Jones, E.A., Chandler, K.E., Orr, D., Moss, C., Haider, Z., Ryan, G., Holden, S., Harrison, M., Burrows, N., Jones, W.D., Loveless, M., Petree, C., Stewart, H., Low, K., Donnelly, D., Lovell, S., Drosou, K., Genomics England Research Consortium, Solve-RD consortium, Varshney, G.K., Banka, S. (2023) Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14. HGG advances. 4:100186100186
- Coltogirone, R.A., Sherfinski, E.I., Dobler, Z.A., Peterson, S.N., Andlinger, A.R., Fadel, L.C., Patrick, R.L., Bergeron, S.A. (2022) Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(3):377-399
- Liu, Z., Sun, H., Dai, J., Xue, X., Sun, J., Wang, X. (2021) ITPR1 Mutation Contributes to Hemifacial Microsomia Spectrum. Frontiers in genetics. 12:616329
- Suzuki, T., Hirai, Y., Uehara, T., Ohga, R., Kosaki, K., Kawahara, A. (2021) Involvement of the zebrafish trrap gene in craniofacial development. Scientific Reports. 11:24166
- Chen, Z., Song, Z., Yang, J., Huang, J., Jiang, H. (2019) Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae. Journal of biosciences. 44(6):
- Gibert, Y., Samarut, E., Ellis, M.K., Jackman, W.R., Laudet, V. (2019) The first formed tooth serves as a signalling centre to induce the formation of the dental row in zebrafish. Proceedings. Biological sciences. 286:20190401
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Zhang, Y., Ji, D., Li, L., Yang, S., Zhang, H., Duan, X. (2019) ClC-7 Regulates the Pattern and Early Development of Craniofacial Bone and Tooth. Theranostics. 9:1387-1400
- Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G. (2018) Fox proteins are modular competency factors for facial cartilage and tooth specification. Development (Cambridge, England). 145(12)
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