Gene
ednrba
- ID
- ZDB-GENE-980526-16
- Name
- endothelin receptor Ba
- Symbol
- ednrba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable endothelin receptor activity. Acts upstream of or within iridophore differentiation and regulation of developmental pigmentation. Predicted to be active in plasma membrane. Is expressed in gill; head; iridophore; pigment cell; and trunk. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome (multiple); asthma; and pulmonary hypertension. Orthologous to human EDNRB (endothelin receptor type B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ABCD syndrome | Alliance | ?ABCD syndrome | 600501 |
| Waardenburg syndrome type 4A | Alliance | Waardenburg syndrome, type 4A | 277580 |
| {Hirschsprung disease, susceptibility to, 2} | 600155 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Endothelin receptor B | Endothelin receptor family | GPCR, rhodopsin-like, 7TM | G-protein coupled endothelin receptor | G protein-coupled receptor, rhodopsin-like | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DGM2 | InterPro | 426 | |||||||
| UniProtKB:A0AB32TSC5 | InterPro | 373 | |||||||
| UniProtKB:A0AB32TTH1 | InterPro | 536 | |||||||
| UniProtKB:A0AB32TVM6 | InterPro | 519 | |||||||
| UniProtKB:A0A2R8QIT0 | InterPro | 390 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ednrba-001 (1) | Havana | 1,492 nt | ||
| mRNA |
ednrba-201
(1)
|
Ensembl | 1,489 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Varady, A., Grissenberger, S., Wenninger-Weinzierl, A., Poplimont, H., Sturtzel, C., Schmitner, N., Gao, L., Kimmel, R.A., Distel, M. (2025) Precise photopharmacological eradication of metastatic tumor cells. Disease models & mechanisms. 18:
- Dernovšek, J., Urbančič, D., Zajec, Ž., Sturtzel, C., Grissenberger, S., Wenninger-Weinzierl, A., Gedgaudas, M., Zubrienė, A., Goričan, T., Golič Grdadolnik, S., Skok, Ž., Ilaš, J., Distel, M., Zidar, N., Tomašič, T. (2024) First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo. Bioorganic chemistry. 153:107850107850
- Dernovšek, J., Zajec, Ž., Poje, G., Urbančič, D., Sturtzel, C., Goričan, T., Grissenberger, S., Ciura, K., Woziński, M., Gedgaudas, M., Zubrienė, A., Grdadolnik, S.G., Mlinarič-Raščan, I., Rajić, Z., Cotman, A.E., Zidar, N., Distel, M., Tomašič, T. (2024) Exploration and optimisation of structure-activity relationships of new triazole-based C-terminal Hsp90 inhibitors towards in vivo anticancer potency. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 177:116941116941
- Schmitner, N., Thumer, S., Regele, D., Mayer, E., Bergerweiss, I., Helker, C., Stainier, D.Y.R., Meyer, D., Kimmel, R.A. (2024) Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes. Communications biology. 7:15571557
- Yen, J.H., Keak, P.Y., Wu, C.L., Chen, H.J., Gao, W.Y., Liou, J.W., Chen, Y.R., Lin, L.I., Chen, P.Y. (2024) Shikonin, a natural naphthoquinone phytochemical, exerts anti-leukemia effects in human CBF-AML cell lines and zebrafish xenograft models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 179:117395117395
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Freudenblum, J., Meyer, D., Kimmel, R.A. (2022) Mitochondrial network expansion and dynamic redistribution during islet morphogenesis in zebrafish larvae. FEBS letters. 597(2):262-275
- Gabler, L., Jaunecker, C.N., Katz, S., van Schoonhoven, S., Englinger, B., Pirker, C., Mohr, T., Vician, P., Stojanovic, M., Woitzuck, V., Laemmerer, A., Kirchhofer, D., Mayr, L., LaFranca, M., Erhart, F., Grissenberger, S., Wenninger-Weinzierl, A., Sturtzel, C., Kiesel, B., Lang, A., Marian, B., Grasl-Kraupp, B., Distel, M., Schüler, J., Gojo, J., Grusch, M., Spiegl-Kreinecker, S., Donoghue, D.J., Lötsch, D., Berger, W. (2022) Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness. Acta neuropathologica communications. 10:65
- Grissenberger, S., Sturtzel, C., Wenninger-Weinzierl, A., Radic-Sarikas, B., Scheuringer, E., Bierbaumer, L., Etienne, V., Némati, F., Pascoal, S., Tötzl, M., Tomazou, E., Metzelder, M., Putz, E.M., Decaudin, D., Delattre, O., Surdez, D., Kovar, H., Halbritter, F., Distel, M. (2022) High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-XL inhibition against Ewing sarcoma. Cancer letters. 554:216028
- Schelch, K., Eder, S., Zitta, B., Phimmachanh, M., Johnson, T.G., Emminger, D., Wenninger-Weinzierl, A., Sturtzel, C., Poplimont, H., Ries, A., Hoetzenecker, K., Hoda, M.A., Berger, W., Distel, M., Dome, B., Reid, G., Grusch, M. (2022) YB-1 regulates mesothelioma cell migration via Snail but not EGFR, MMP1, EPHA5 or PARK2. Molecular Oncology. 18(4):815-831
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