Gene
foxd3
- ID
- ZDB-GENE-980526-143
- Name
- forkhead box D3
- Symbol
- foxd3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within several processes, including iridophore differentiation; negative regulation of macromolecule biosynthetic process; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including mesoderm; nervous system; neural crest; neural keel; and neural plate. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human FOXD3 (forkhead box D3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 203 figures from 151 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct110aGt | Transgenic insertion | Unknown | Unknown | DNA | |
| ct110aRGt | Transgenic insertion | Unknown | Unknown | DNA | |
| ihb666 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| ihb667 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| m188 | unknown | Unknown | Unknown | ENU | |
| sa174 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa20726 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zdf10 | Allele with one deletion | Unknown | Frameshift, Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Autoimmune disease, susceptibility to, 1} | 607836 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047392 | Forkhead box protein D3, forkhead domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein D3, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R5S7 | InterPro | 371 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(foxd3:EGFP) |
|
| 1 | (4) | |
| Tg(foxd3:GFP) |
|
| 3 | (100) | |
| TgBAC(foxd3:AVI-2A-Citrine) |
|
| 1 | (2) | |
| TgBAC(foxd3:EGFP) |
|
| 1 | Cooper et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-148H10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111934 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131290 (1) | 1799 nt | ||
| Genomic | GenBank:BX664614 (1) | 184225 nt | ||
| Polypeptide | UniProtKB:F1R5S7 (1) | 371 aa |
- Huang, D., Kapadia, E.H., Liang, Y., Shriver, L.P., Dai, S., Patti, G.J., Humbel, B.M., Laudet, V., Parichy, D.M. (2025) Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 122:e2424180122e2424180122
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Xia, X., Song, W., Zhang, F., Fan, Y., Zhang, B., Chen, X. (2025) ctdsp2 Knockout Induces Zebrafish Craniofacial Dysplasia via p53 Signaling Activation. International Journal of Molecular Sciences. 26:
- Guo, X., Yang, L., Wang, Y., Yuan, M., Zhang, W., He, X., Wang, Q. (2024) Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. :
- Li, D., Tian, Y., Vona, B., Yu, X., Lin, J., Ma, L., Lou, S., Li, X., Zhu, G., Wang, Y., Du, M., Wang, L., Pan, Y. (2024) A TAF11 variant contributes to non-syndromic cleft lip only through modulating neural crest cell migration. Human molecular genetics. :
- Niu, X., Zhang, F., Gu, W., Zhang, B., Chen, X. (2024) FBLN2 is associated with Goldenhar syndrome and is essential for cranial neural crest cell development. Annals of the New York Academy of Sciences. 1537(1):113-128
- Song, W., Xia, X., Fan, Y., Zhang, B., Chen, X. (2024) Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. International Journal of Molecular Sciences. 25(9):
- Sun, L., Ping, L., Fan, X., Fan, Y., Zhang, B., Chen, X. (2024) amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway. International Journal of Molecular Sciences. 25(2):
- Tignard, P., Pottin, K., Geeverding, A., Doulazmi, M., Cabrera, M., Fouquet, C., Liffran, M., Fouchard, J., Rosello, M., Albadri, S., Del Bene, F., Trembleau, A., Breau, M.A. (2024) Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development. eLIFE. 12:
- Williams, A.L., Bohnsack, B.L. (2024) Keratin 8/18a.1 Expression Influences Embryonic Neural Crest Cell Dynamics and Contributes to Postnatal Corneal Regeneration in Zebrafish. Cells. 13(17):
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