Gene
pou3f3b
- ID
- ZDB-GENE-980526-140
- Name
- POU class 3 homeobox 3b
- Symbol
- pou3f3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including head; nervous system; otic vesicle; pronephric duct; and spinal cord neural tube. Orthologous to human POU3F3 (POU class 3 homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Barske et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pou3f3b | (2) | |
| CRISPR2-pou3f3b | (2) | |
| CRISPR3-pou3f3b | (2) | |
| TALEN1-pou3f3b | Barske et al., 2020 |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Snijders Blok-Fisher syndrome | 618604 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily | POU domain | POU domain transcription factor | POU-domain transcription factor, class 3 | POU-specific domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:P79745 | InterPro | 443 | ||||||||
| UniProtKB:A0A8M2BFZ4 | InterPro | 440 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pou3f3b-201
(1)
|
Ensembl | 3,403 nt | ||
| mRNA |
pou3f3b-202
(1)
|
Ensembl | 3,093 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(UAS:pou3f3b,cryaa:Cerulean) |
|
| 1 | Barske et al., 2020 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-30B17 | ZFIN Curated Data | |
| Encodes | EST | fb92g06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65734 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65766 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195009 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131102 (1) | 3443 nt | ||
| Genomic | GenBank:CU929521 (1) | 48746 nt | ||
| Polypeptide | UniProtKB:P79745 (1) | 443 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Fabian, P., Tseng, K.C., Thiruppathy, M., Arata, C., Chen, H.J., Smeeton, J., Nelson, N., Crump, J.G. (2022) Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. Nature communications. 13:13
- Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B. (2022) Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear. Developmental Biology. 492:139-153
- Xu, P., Yu, H.V., Tseng, K.C., Flath, M., Fabian, P., Segil, N., Crump, J.G. (2021) Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation. eLIFE. 10:
- Barske, L., Fabian, P., Hirschberger, C., Jandzik, D., Square, T., Xu, P., Nelson, N., Yu, H.V., Medeiros, D.M., Gillis, J.A., Crump, J.G. (2020) Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Proceedings of the National Academy of Sciences of the United States of America. 117(40):24876-24884
- Kantarci, H., Gou, Y., Riley, B.B. (2020) The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle. eLIFE. 9:
- Cosse-Etchepare, C., Gervi, I., Buisson, I., Formery, L., Schubert, M., Riou, J.F., Umbhauer, M., Le Bouffant, R. (2018) Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. The International journal of developmental biology. 62:325-333
- Gou, Y., Vemaraju, S., Sweet, E.M., Kwon, H.J., Riley, B.B. (2018) sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear. Developmental Biology. 435(1):73-83
- Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
- Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D. (2016) Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm. Developmental Biology. 411(1):101-14
1 - 10 of 28
Show