Gene
ndrg3a
- ID
- ZDB-GENE-980526-124
- Name
- ndrg family member 3a
- Symbol
- ndrg3a Nomenclature History
- Previous Names
-
- ndr3
- ndrg3
- fc04h03
- wu:fc04h03
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to be involved in signal transduction. Predicted to act upstream of or within nervous system development. Predicted to be active in cytoplasm. Is expressed in several structures, including corpuscles of Stannius; pectoral fin bud; pharyngeal pouch; pronephric duct; and thymus. Orthologous to human NDRG3 (NDRG family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Li et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa35087 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | NDRG |
---|---|---|---|---|
UniProtKB:Q7SY38 | InterPro | 362 | ||
UniProtKB:E7FEZ7 | InterPro | 362 | ||
UniProtKB:A0A8M9PUP4 | InterPro | 375 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ndrg3a-201
(1)
|
Ensembl | 1,951 nt | ||
mRNA |
ndrg3a-202
(1)
|
Ensembl | 3,832 nt | ||
mRNA |
ndrg3a-203
(1)
|
Ensembl | 1,162 nt | ||
mRNA |
ndrg3a-204
(1)
|
Ensembl | 998 nt | ||
mRNA |
ndrg3a-206
(1)
|
Ensembl | 3,685 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-25D12 | ZFIN Curated Data | |
Contained in | BAC | CH211-274P22 | ZFIN Curated Data | |
Encodes | EST | fc04h03 | ||
Encodes | cDNA | MGC:63551 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199517 (1) | 1953 nt | ||
Genomic | GenBank:CR555298 (1) | 183135 nt | ||
Polypeptide | UniProtKB:A0A8M9PUP4 (1) | 375 aa |
- Park, J.S., Gabel, A.M., Kassir, P., Kang, L., Chowdhary, P.K., Osei-Ntansah, A., Tran, N.D., Viswanathan, S., Canales, B., Ding, P., Lee, Y.S., Brewster, R. (2022) N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. eLIFE. 11:
- Simsek, M.F., Chandel, A.S., Saparov, D., Zinani, O.Q.H., Clason, N., Özbudak, E.M. (2022) Periodic inhibition of Erk activity drives sequential somite segmentation. Nature. 613(7942):153-159
- Zinani, O.Q.H., Keseroğlu, K., Dey, S., Ay, A., Singh, A., Özbudak, E.M. (2022) Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes. iScience. 25:104579
- Le, N., Hufford, T.M., Park, J.S., Brewster, R.M. (2021) Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21961
- She, P., Zhang, H., Peng, X., Sun, J., Gao, B., Zhou, Y., Zhu, X., Hu, X., Lai, K.S., Wong, J., Zhou, B., Wang, L., Zhong, T.P. (2020) The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development (Cambridge, England). 147(18):
- Zinani, O.Q.H., Keseroğlu, K., Ay, A., Özbudak, E.M. (2020) Pairing of segmentation clock genes drives robust pattern formation. Nature. 589(7842):431-436
- Yan, Y.L., Batzel, P., Titus, T., Sydes, J., Desvignes, T., Bremiller, R., Draper, B., Postlethwait, J.H. (2019) A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination. Genetics. 213(2):529-553
- Sari, D.W.K., Akiyama, R., Naoki, H., Ishijima, H., Bessho, Y., Matsui, T. (2018) Time-lapse observation of stepwise regression of Erk activity in zebrafish presomitic mesoderm. Scientific Reports. 8:4335
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Gallagher, T.L., Tietz, K.T., Morrow, Z.T., McCammon, J.M., Goldrich, M.L., Derr, N.L., Amacher, S.L. (2017) Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Developmental Biology. 429(1):225-239
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