Gene
epob
- ID
- ZDB-GENE-141216-428
- Name
- erythropoietin b
- Symbol
- epob Nomenclature History
- Previous Names
-
- si:dkey-259i8.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable erythropoietin receptor binding activity; protein kinase activator activity; and receptor ligand activity. Predicted to be involved in cell surface receptor signaling pathway via STAT; erythrocyte differentiation; and erythropoietin-mediated signaling pathway. Predicted to act upstream of or within erythrocyte maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from She et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from She et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial erythrocytosis 5 | Alliance | Erythrocytosis, familial, 5 | 617907 |
| ?Diamond-Blackfan anemia-like | 617911 | ||
| {Microvascular complications of diabetes 2} | 612623 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Erythropoietin | Erythropoietin/thrombopoietin | Four-helical cytokine-like, core |
|---|---|---|---|---|---|
| UniProtKB:A0A8M3AWM3 | InterPro | 181 | |||
| UniProtKB:A0A8M9QCG3 | InterPro | 182 |
Interactions and Pathways
No data available
Plasmids
No data available