Gene
myo5c
- ID
- ZDB-GENE-131127-196
- Name
- myosin VC
- Symbol
- myo5c Nomenclature History
- Previous Names
-
- unm_sa3298
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. Is expressed in intestine. Orthologous to human MYO5C (myosin VC).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sidhaye et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa3291 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa3298 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa6792 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa6793 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa9570 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11146 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa11888 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12025 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa14963 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa16770 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Class V myosin, motor domain | Dilute domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin 5c, cargo-binding domain | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7FCI5 | InterPro | 1746 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-286K11 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_686051 (1) | 5714 nt | ||
Genomic | GenBank:AL954697 (1) | 134798 nt | ||
Polypeptide | UniProtKB:E7FCI5 (1) | 1746 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sidhaye, J., Pinto, C.S., Dharap, S., Jacob, T., Bhargava, S., Sonawane, M. (2016) The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease. Mechanisms of Development. 142:62-74
- Sonal, ., Sidhaye, J., Phatak, M., Banerjee, S., Mulay, A., Deshpande, O., Bhide, S., Jacob, T., Gehring, I., Nuesslein-Volhard, C., Sonawane, M. (2014) Myosin Vb Mediated Plasma Membrane Homeostasis Regulates Peridermal Cell Size and Maintains Tissue Homeostasis in the Zebrafish Epidermis. PLoS Genetics. 10:e1004614
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