Gene
myo5c
- ID
- ZDB-GENE-131127-196
- Name
- myosin VC
- Symbol
- myo5c Nomenclature History
- Previous Names
-
- unm_sa3298
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. Is expressed in intestine. Orthologous to human MYO5C (myosin VC).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sidhaye et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa3291 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa3298 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6792 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6793 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9570 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11146 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11888 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12025 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14963 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16770 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Class V myosin, motor domain | Dilute domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin 5c, cargo-binding domain | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FCI5 | InterPro | 1746 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-286K11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_686051 (1) | 5714 nt | ||
| Genomic | GenBank:AL954697 (1) | 134798 nt | ||
| Polypeptide | UniProtKB:E7FCI5 (1) | 1746 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sidhaye, J., Pinto, C.S., Dharap, S., Jacob, T., Bhargava, S., Sonawane, M. (2016) The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease. Mechanisms of Development. 142:62-74
- Sonal, ., Sidhaye, J., Phatak, M., Banerjee, S., Mulay, A., Deshpande, O., Bhide, S., Jacob, T., Gehring, I., Nuesslein-Volhard, C., Sonawane, M. (2014) Myosin Vb Mediated Plasma Membrane Homeostasis Regulates Peridermal Cell Size and Maintains Tissue Homeostasis in the Zebrafish Epidermis. PLoS Genetics. 10:e1004614
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