Gene
pdgfbb
- ID
- ZDB-GENE-131121-332
- Name
- platelet-derived growth factor beta polypeptide b
- Symbol
- pdgfbb Nomenclature History
- Previous Names
-
- sb:eu2436
- si:dkey-110g7.5
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable platelet-derived growth factor receptor binding activity. Involved in several processes, including epicardial cell to mesenchymal cell transition; negative regulation of adherens junction organization; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in extracellular space. Is expressed in several structures, including basal plate midbrain region; brain; forebrain neural keel; forebrain neural rod; and notochord. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2436 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pdgfbb | Stratman et al., 2020 | |
| CRISPR2-pdgfbb | Ando et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 5 | 615483 |
| Meningioma, SIS-related | 607174 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PEQ6 | InterPro | 483 | |||
| UniProtKB:A0A2R8Q0D8 | InterPro | 483 | |||
| UniProtKB:A0A8M9PWR6 | InterPro | 482 | |||
| UniProtKB:A0A8M9PRI9 | InterPro | 482 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pdgfbb-201
(1)
|
Ensembl | 3,821 nt | ||
| mRNA |
pdgfbb-202
(1)
|
Ensembl | 4,898 nt | ||
| mRNA |
pdgfbb-203
(1)
|
Ensembl | 7,212 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-110G7 | ZFIN Curated Data | |
| Encodes | EST | eu2436 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005171611 (1) | 3260 nt | ||
| Genomic | GenBank:CR812472 (1) | 194804 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q0D8 (1) | 483 aa |
- Lee, J., Goeckel, M.E., Levitas, A., Colijn, S., Shin, J., Hindes, A., Mun, G., Burton, Z., Chintalapati, B., Yin, Y., Abello, J., Solnica-Krezel, L., Stratman, A. (2024) CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment. Arteriosclerosis, Thrombosis, and Vascular Biology. 44(12):2577-2595
- Murayama, E., Vivier, C., Schmidt, A., Herbomel, P. (2023) Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nature communications. 14:11711171
- Ribeiro, A., Rebocho da Costa, M., de Sena-Tomás, C., Rodrigues, E.C., Quitéria, R., Maçarico, T., Rosa Santos, S.C., Saúde, L. (2023) Development and repair of blood vessels in the zebrafish spinal cord. Open Biology. 13:230103230103
- Ando, K., Shih, Y.H., Ebarasi, L., Grosse, A., Portman, D., Chiba, A., Mattonet, K., Gerri, C., Stainier, D.Y.R., Mochizuki, N., Fukuhara, S., Betsholtz, C., Lawson, N.D. (2021) Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development. Developmental Biology. 479:11-22
- Stratman, A.N., Burns, M.C., Farrelly, O.M., Davis, A.E., Li, W., Pham, V.N., Castranova, D., Yano, J.J., Goddard, L.M., Nguyen, O., Galanternik, M.V., Bolan, T.J., Kahn, M.L., Mukouyama, Y.S., Weinstein, B.M. (2020) Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment. Communications biology. 3:734
- Tsata, V., Möllmert, S., Schweitzer, C., Kolb, J., Möckel, C., Böhm, B., Rosso, G., Lange, C., Lesche, M., Hammer, J., Kesavan, G., Beis, D., Guck, J., Brand, M., Wehner, D. (2020) A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Developmental Cell. 56(4):509-524.e9
- Zhou, Z., Zheng, L., Tang, C., Chen, Z., Zhu, R., Peng, X., Wu, X., Zhu, P. (2020) Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in Physiology. 11:565307
- Mullapudi, S.T., Boezio, G.L.M., Rossi, A., Marass, M., Matsuoka, R.L., Matsuda, H., Helker, C.S.M., Yang, Y.H.C., Stainier, D.Y.R. (2019) Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development (Cambridge, England). 146(21):
- Shi, H., Wang, H., Yao, J., Lin, C., Wei, Q., Lu, Y., Cao, X. (2019) Comparative transcriptome analysis of auditory OC-1 cells and zebrafish inner ear tissues in the absence of human OSBPL2 orthologues. Biochemical and Biophysical Research Communications. 521(1):42-49
- Lim, S.E., Esain, V., Kwan, W., Theodore, L.N., Cortes, M., Frost, I.M., Liu, S.Y., North, T.E. (2017) HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Experimental hematology. 46:83-95.e6
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