Gene
prkd2
- ID
- ZDB-GENE-131120-142
- Name
- protein kinase D2
- Symbol
- prkd2 Nomenclature History
- Previous Names
-
- bua
- si:dkey-202l22.2
- unm s411
- unm_s411
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within endocardial cushion formation. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Is expressed in brain; gut; and heart. Orthologous to human PRKD2 (protein kinase D2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Just et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-prkd2 | N/A | Just et al., 2011 |
MO2-prkd2 | N/A | Giardoglou et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001849 | Pleckstrin homology domain |
Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase C mu-related | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PLD4 | InterPro | 923 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-9F1 | ZFIN Curated Data | |
Contained in | BAC | DKEY-202L22 | ZFIN Curated Data | |
Encodes | EST | fj10e04 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_021466325 (1) | 4348 nt | ||
Genomic | GenBank:FO704748 (1) | 206751 nt | ||
Polypeptide | UniProtKB:A0A8M9PLD4 (1) | 923 aa |
- Giardoglou, P., Bournele, D., Park, M., Kanoni, S., Dedoussis, G.V., Steinberg, S.F., Deloukas, P., Beis, D. (2021) A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2. Biology Open. 10(3):
- Just, S., Berger, I.M., Meder, B., Backs, J., Keller, A., Marquart, S., Frese, K., Patzel, E., Rauch, G.J., Tübingen 2000 Screen Consortium, Katus, H.A., and Rottbauer, W. (2011) Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity. Circulation. 124(3):324-34
- Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204
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