Gene
tln2b
- ID
- ZDB-GENE-130325-1
- Name
- talin 2b
- Symbol
- tln2b Nomenclature History
- Previous Names
-
- si:ch1073-300g4.1
- zmp:0000000620 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cell junction assembly. Predicted to act upstream of or within cell adhesion. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and ruffle. Is expressed in brain; ectoderm; head; paraxial mesoderm; and somite. Orthologous to human TLN2 (talin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wu et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9473 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11842 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13127 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17241 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32542 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44343 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sk112 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tln2b | Yamaguchi et al., 2022 | |
| CRISPR2-tln2b | Yamaguchi et al., 2022 | |
| CRISPR3-tln2b | Yamaguchi et al., 2022 | |
| CRISPR4-tln2b | Yamaguchi et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-catenin/vinculin-like superfamily | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM central domain | FERM conserved site | FERM domain | FERM superfamily, second domain | I/LWEQ domain | I/LWEQ domain superfamily | IRS-type PTB domain | PH-like domain superfamily | Talin-1/2, rod-segment | Talin 1-like, rod-segment domain | Talin, central | Talin, central domain superfamily | Talin, IBS2B domain | Talin, N-terminal F0 domain | Talin, R4 domain | Ubiquitin-like domain superfamily | Vinculin-binding site-containing domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TJL8 | InterPro | 2578 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-300G4 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068217562 (1) | 14219 nt | ||
| Genomic | GenBank:FO904882 (1) | 37306 nt | ||
| Polypeptide | UniProtKB:A0AB32TJL8 (1) | 2578 aa |
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Wu, Y., Lou, Q.Y., Ge, F., Xiong, Q. (2017) Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Scientific Reports. 7:4022
- Wu, Q., Zhang, J., Koh, W., Yu, Q., Zhu, X., Amsterdam, A., Davis, G.E., Arnaout, M.A., Xiong, J.W. (2015) Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(12):4989-5005
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