Gene
hemgn
- ID
- ZDB-GENE-121214-307
- Name
- hemogen
- Symbol
- hemgn Nomenclature History
- Previous Names
-
- si:dkey-25o16.2
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Acts upstream of or within erythrocyte differentiation. Is expressed in several structures, including brain; erythroblast; hematopoietic system; lateral plate mesoderm; and pleuroperitoneal region. Orthologous to human HEMGN (hemogen).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Peters et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-hemgn | (3) | |
MO1-hemgn | N/A | Peters et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein | Additional Resources | Length |
---|---|---|
UniProtKB:R4GE89 | InterPro | 198 |
UniProtKB:R4GDZ7 | InterPro | 194 |
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Interactions and Pathways
No data available
Plasmids
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-25O16 | ZFIN Curated Data | |
interacts with | NC Conserved Region (CNE, CNS) | nccr.hemgn.1 | Peters et al., 2018 | |
interacts with | NC Conserved Region (CNE, CNS) | nccr.hemgn.2 | Peters et al., 2018 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_700557 (1) | 1047 nt | ||
Genomic | GenBank:BX005000 (2) | 194243 nt | ||
Polypeptide | UniProtKB:R4GE89 (1) | 198 aa |
- Gimenez, G., Kalev-Zylinska, M.L., Morison, I., Bohlander, S.K., Horsfield, J.A., Antony, J. (2024) Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. American journal of physiology. Cell physiology. 328(1):C9-C19
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Peters, M.J., Parker, S.K., Grim, J., Allard, C.A.H., Levin, J., Detrich, H.W. (2018) Divergent Hemogen genes of teleosts and mammals share conserved roles in erythropoiesis: analysis using transgenic and mutant zebrafish.. Biology Open. 7(8):
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