Gene
gmnc
- ID
- ZDB-GENE-121211-1
- Name
- geminin coiled-coil domain containing
- Symbol
- gmnc Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Acts upstream of or within multi-ciliated epithelial cell differentiation. Predicted to be active in nucleus. Is expressed in nervous system and pronephric duct. Orthologous to human GMNC (geminin coiled-coil domain containing).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gmnc | (4) | |
| CRISPR2-gmnc | Zhou et al., 2015 | |
| MO1-gmnc | N/A | Zhou et al., 2015 |
| MO2-gmnc | N/A | Zhou et al., 2015 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:E7FDS4 | InterPro | 382 |
| UniProtKB:A0A8M3AQ26 | InterPro | 295 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-23K10 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-75C7 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009291838 (1) | 1517 nt | ||
| Genomic | GenBank:BX571739 (1) | 139312 nt | ||
| Polypeptide | UniProtKB:E7FDS4 (1) | 382 aa |
- Comparative Orthology
- Alliance
- D'Gama, P.P., Qiu, T., Cosacak, M.I., Rayamajhi, D., Konac, A., Hansen, J.N., Ringers, C., Acuña-Hinrichsen, F., Hui, S.P., Olstad, E.W., Chong, Y.L., Lim, C.K.A., Gupta, A., Ng, C.P., Nilges, B.S., Kashikar, N.D., Wachten, D., Liebl, D., Kikuchi, K., Kizil, C., Yaksi, E., Roy, S., Jurisch-Yaksi, N. (2021) Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell Reports. 37:109775
- Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
- Zhou, F., Rayamajhi, D., Ravi, V., Narasimhan, V., Chong, Y.L., Lu, H., Venkatesh, B., Roy, S. (2020) Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates. Developmental Biology. 465(2):168-177
- Lu, H., Anujan, P., Zhou, F., Zhang, Y., Chong, Y.L., Bingle, C.D., Roy, S. (2019) Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals. Development (Cambridge, England). 146(6):
- Chong, Y.L., Zhang, Y., Zhou, F., Roy, S. (2018) Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Developmental Biology. 443(2):165-172
- Zhou, F., Narasimhan, V., Shboul, M., Chong, Y.L., Reversade, B., Roy, S. (2015) Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program. Current biology : CB. 25(24):3267-73
1 - 6 of 6
Show