Gene
adgrg4a
- ID
- ZDB-GENE-121129-2
- Name
- adhesion G protein-coupled receptor G4a
- Symbol
- adgrg4a Nomenclature History
- Previous Names
-
- gpr112a
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; intestine; and testis. Orthologous to human ADGRG4 (adhesion G protein-coupled receptor G4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | GAIN domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | GPS motif | Pentraxin-related |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z267 | InterPro | 1140 | |||||||
| UniProtKB:A0A140LGW6 | InterPro | 1201 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgrg4a-201
(1)
|
Ensembl | 4,563 nt | ||
| mRNA |
adgrg4a-202
(1)
|
Ensembl | 1,302 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-11E3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021481193 (1) | 4596 nt | ||
| Genomic | GenBank:BX470159 (1) | 210284 nt | ||
| Polypeptide | UniProtKB:A0A140LGW6 (1) | 1201 aa |
- Huang, S., Zhang, H., Chen, W., Su, N., Yuan, C., Zhang, J., Xiang, S., Hu, X. (2023) CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development. Genes. 14(5):
- Torregrosa-Carrión, R., Piñeiro-Sabarís, R., Siguero-Álvarez, M., Grego-Bessa, J., Luna-Zurita, L., Fernandes, V.S., MacGrogan, D., Stainier, D.Y.R., de la Pompa, J.L. (2021) Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Science advances. 7:eabj5445
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Harty, B.L., Krishnan, A., Sanchez, N.E., Schiöth, H.B., Monk, K.R. (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 16:62
- Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374
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