Gene
elfn1a
- ID
- ZDB-GENE-120927-2
- Name
- extracellular leucine-rich repeat and fibronectin type III domain containing 1a
- Symbol
- elfn1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Predicted to be involved in chemical synaptic transmission. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study schizophrenia. Orthologous to human ELFN1 (extracellular leucine rich repeat and fibronectin type III domain containing 1).
- Genome Resources
-
- Alliance (1)
- Gene:562570 (1)
- Note
-
No Ensembl gene model in GRCz11.
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a216 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa6913 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13873 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14082 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14448 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-elfn1a | Thyme et al., 2019 | |
| CRISPR2-elfn1a | Thyme et al., 2019 | |
| CRISPR3-elfn1a | Thyme et al., 2019 | |
| CRISPR4-elfn1a | Thyme et al., 2019 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| schizophrenia | elfn1aa216/a216 | standard conditions | Thyme et al., 2019 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR055106 | ELFN1/ELFN2, fibronectin type-III domain |
| Family | IPR050541 | Leucine-rich repeat and transmembrane domain-containing protein |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | ELFN1/ELFN2, fibronectin type-III domain | Leucine-rich repeat | Leucine-rich repeat and transmembrane domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F8P8 | InterPro | 784 | ||||||
| UniProtKB:A0A8M2BBN8 | InterPro | 797 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005164193 (1) | 4930 nt | ||
| Genomic | GenBank:BX537305 (1) | 186856 nt | ||
| Polypeptide | UniProtKB:A0A8M2BBN8 (1) | 797 aa |
- Comparative Orthology
- Alliance
- Nittoli, V., Fortunato, A.E., Fasano, G., Coppola, U., Gentile, A., Maiella, S., Langellotto, F., Porreca, I., De Paolo, R., Marino, R., Fiengo, M., Donizetti, A., Aniello, F., Kondo, T., Ristoratore, F., Canzoniero, L.M.T., Duboule, D., Wilson, S.W., Sordino, P. (2019) Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Gene X. 2:100011
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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