Gene
kcnj2a
- ID
- ZDB-GENE-120319-1
- Name
- potassium inwardly rectifying channel subfamily J member 2a
- Symbol
- kcnj2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in T-tubule. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including heart; myotome; olfactory system; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kcnj2a | Zebrafish Nomenclature Committee | |
| CRISPR2-kcnj2a | LaCoursiere et al., 2024 | |
| CRISPR3-kcnj2a | LaCoursiere et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Andersen-Tawil syndrome | Alliance | Andersen syndrome | 170390 |
| familial atrial fibrillation | Alliance | Atrial fibrillation, familial, 9 | 613980 |
| short QT syndrome | Alliance | Short QT syndrome 3 | 609622 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013673 | Potassium channel, inwardly rectifying, Kir, N-terminal |
| Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
| Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
| Family | IPR003271 | Potassium channel, inwardly rectifying, Kir2.1 |
| Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir2.1 | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, Kir, N-terminal | Potassium channel, inwardly rectifying, transmembrane domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FGH1 | InterPro | 427 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnj2a-201
(1)
|
Ensembl | 1,515 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(mitfa:kcnj2) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-68J20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001331216 (1) | 5033 nt | ||
| Genomic | GenBank:BX510998 (1) | 148753 nt | ||
| Polypeptide | UniProtKB:E7FGH1 (1) | 427 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Fang, C., Wang, P., Yu, D., Zhang, X., Gou, D., Liang, L., Bai, X., Xie, W., Li, H., Pu, J., Yao, Y., Wang, B., Ren, X., Ke, T., Tu, X., Xu, C., Wang, Q.K. (2022) Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and Cardiac Rhythm Maintenance. Circulation. Genomic and precision medicine. 15(5):e003603
- Silic, M.R., Murata, S.H., Park, S.J., Zhang, G. (2021) Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(4):687-713
- Hassinen, M., Korajoki, H., Abramochkin, D., Krivosheya, P., Vornanen, M. (2019) Transcript expression of inward rectifier potassium channels of Kir2 subfamily in Arctic marine and freshwater fish species. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 189(6):735-749
- Barta, C.L., Liu, H., Chen, L., Giffen, K.P., Li, Y., Kramer, K.L., Beisel, K.W., He, D.Z. (2018) RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells. Scientific data. 5:180005
- Benz, A., Kossack, M., Auth, D., Seyler, C., Zitron, E., Juergensen, L., Katus, H.A., Hassel, D. (2016) miR-19b Regulates Ventricular Action Potential Duration in Zebrafish. Scientific Reports. 6:36033
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Chen, M., Xu, Y., Huang, R., Huang, Y., Ge, S., Hu, B. (2016) N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo. Molecular neurobiology. 54(9):6917-6930
- Zhou, J., Wang, L., Zuo, M., Wang, X., Ahmed, A.S., Chen, Q., Wang, Q.K. (2016) Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm. Scientific Reports. 6:21538
- Hassinen, M., Haverinen, J., Hardy, M.E., Shiels, H.A., Vornanen, M. (2015) Inward rectifier potassium current (I K1) and Kir2 composition of the zebrafish (Danio rerio) heart. Pflugers Archiv : European journal of physiology. 467(12):2437-46
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