Gene
onecut2
- ID
- ZDB-GENE-120215-73
- Name
- one cut homeobox 2
- Symbol
- onecut2 Nomenclature History
- Previous Names
-
- si:ch1073-41k10.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain and retina. Orthologous to human ONECUT2 (one cut homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12421 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CUT domain | CUT Homeobox Domain-Containing Protein | Homedomain-like superfamily | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PU69 | InterPro | 407 | |||||
| UniProtKB:A0A8M1QUT6 | InterPro | 461 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
onecut2-201
(1)
|
Ensembl | 1,379 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-99C17 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-41K10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001920273 (1) | |||
| Genomic | GenBank:CU896635 (1) | 88881 nt | ||
| Polypeptide | UniProtKB:A0A8M1QUT6 (1) | 461 aa |
- Vassalli, Q.A., Fasano, G., Nittoli, V., Gagliardi, E., Sepe, R.M., Donizetti, A., Aniello, F., Sordino, P., Kelsh, R., Locascio, A. (2024) The Zebrafish Retina and the Evolution of the Onecut-Mediated Pathway in Cell Type Differentiation. Cells. 13(24):
- Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8
- Wang, J., Chen, Y., Zeng, Z., Feng, R., Wang, Q., Zhang, Q., Sun, K., Chen, A.F., Lu, Y., Yu, Y. (2021) HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Experimental cell research. 408(1):112831
- Madelaine, R., Sloan, S.A., Huber, N., Notwell, J.H., Leung, L.C., Skariah, G., Halluin, C., Paşca, S.P., Bejerano, G., Krasnow, M.A., Barres, B.A., Mourrain, P. (2017) MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis. Cell Reports. 20:1533-1542
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