Gene
htr2ab
- ID
- ZDB-GENE-120215-60
- Name
- 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b
- Symbol
- htr2ab Nomenclature History
- Previous Names
-
- si:dkey-276l13.4
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Acts upstream of or within commissural neuron axon guidance. Predicted to be located in several cellular components, including axon; caveola; and presynapse. Predicted to be active in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Xing et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-htr2ab | Xing et al., 2015 | |
| MO1-htr2ab | N/A | Xing et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| melancholic depression | Alliance | {Major depressive disorder, response to citalopram therapy in} | 608516 |
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
| {Obsessive-compulsive disorder, susceptibility to} | 164230 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 5-Hydroxytryptamine 2A receptor | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B093 | InterPro | 458 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
htr2ab-201
(1)
|
Ensembl | 1,552 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-276L13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_683178 (1) | 2416 nt | ||
| Genomic | GenBank:BX511272 (1) | 193311 nt | ||
| Polypeptide | UniProtKB:A0A8M3B093 (1) | 458 aa |
- Griffin, A., Hamling, K.R., Knupp, K., Hong, S., Lee, L.P., Baraban, S.C. (2017) Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. Brain : a journal of neurology. 140(3):669-683
- Sourbron, J., Schneider, H., Kecskés, A., Liu, Y., Buening, E.M., Lagae, L., Smolders, I., de Witte, P.A. (2016) Serotonergic Modulation as Effective Treatment for Dravet syndrome in a Zebrafish Mutant Model. ACS Chemical Neuroscience. 7(5):588-98
- Xing, L., Son, J.H., Stevenson, T.J., Lillesaar, C., Bally-Cuif, L., Dahl, T., Bonkowsky, J.L. (2015) A Serotonin Circuit Acts as an Environmental Sensor to Mediate Midline Axon Crossing through EphrinB2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:14794-808
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