Gene
ago2
- ID
- ZDB-GENE-110606-6
- Name
- argonaute RISC catalytic component 2
- Symbol
- ago2 Nomenclature History
- Previous Names
-
- Ago2 (1)
- eif2c2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables miRNA binding activity and pre-miRNA binding activity. Acts upstream of or within nucleate erythrocyte differentiation and pre-miRNA processing. Predicted to be located in P-body. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in several structures, including eye; fin; integument; intermediate cell mass of mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Orthologous to human AGO2 (argonaute RISC catalytic component 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa196 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa23583 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa23584 | Allele with one point mutation | Unknown | Splice Site | ENU | |
ya100 | Allele with one deletion | Unknown | Unknown | zinc finger nuclease |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Lessel-Kreienkamp syndrome | 619149 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Argonaute-like, PIWI domain | Argonaute, linker 1 domain | Argonaute linker 2 domain | PAZ domain | PAZ domain superfamily | Piwi domain | Protein argonaute-2 | Protein argonaute, Mid domain | Protein argonaute, N-terminal | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3AKD0 | InterPro | 898 | |||||||||||
UniProtKB:K4I874 | InterPro | 873 |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-351F10 | ||
Contained in | BAC | CH211-57N23 | ||
Encodes | EST | wz1283 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001302222 (1) | 2941 nt | ||
Genomic | GenBank:CU896645 | 162129 nt | ||
Polypeptide | UniProtKB:A0A8M3AKD0 (1) | 898 aa |
- Comparative Orthology
- Alliance
- Wu, L., Zhao, M., Chen, X., Wang, H. (2024) A miR-219-5p-bmal1b negative feedback loop contributes to circadian regulation in zebrafish. Communications biology. 7:16711671
- Kretov, D.A., Walawalkar, I.A., Mora-Martin, A., Shafik, A.M., Moxon, S., Cifuentes, D. (2020) Ago2-Dependent Processing Allows miR-451 to Evade the Global MicroRNA Turnover Elicited during Erythropoiesis. Molecular Cell. 78(2):317-328.e6
- Liu, Y., Zhu, Z., Ho, I.H.T., Shi, Y., Li, J., Wang, X., Chan, M.T.V., Cheng, C.H.K. (2020) Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Frontiers in genetics. 11:853
- Martínez, R., Tu, W., Eng, T., Allaire-Leung, M., Piña, B., Navarro-Martín, L., Mennigen, J.A. (2020) Acute and long-term metabolic consequences of early developmental Bisphenol A exposure in zebrafish (Danio rerio). Chemosphere. 256:127080
- Raman, R., Ryon, M., Jagadeeswaran, P. (2020) RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish. Scientific Reports. 10:20187
- Zhu, Z., Liu, Y., Xu, W., Liu, T., Xie, Y., Sham, K.W.Y., Sha, O., Cheng, C.H.K. (2020) Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Frontiers in genetics. 11:299
- Martinez, R., Vera-Chang, M.N., Haddad, M., Zon, J., Navarro-Martin, L., Trudeau, V.L., Mennigen, J.A. (2019) Developmental fluoxetine exposure in zebrafish reduces offspring basal cortisol concentration via life stage-dependent maternal transmission. PLoS One. 14:e0212577
- Moro, A., Driscoll, T.P., Boraas, L.C., Armero, W., Kasper, D.M., Baeyens, N., Jouy, C., Mallikarjun, V., Swift, J., Ahn, S.J., Lee, D., Zhang, J., Gu, M., Gerstein, M., Schwartz, M., Nicoli, S. (2019) MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis. Nature cell biology. 21(3):348-358
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Chen, G.R., Sive, H., Bartel, D.P. (2017) A Seed Mismatch Enhances Argonaute2-Catalyzed Cleavage and Partially Rescues Severely Impaired Cleavage Found in Fish. Molecular Cell. 68:1095-1107.e5
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