Gene

ago2

ID
ZDB-GENE-110606-6
Name
argonaute RISC catalytic component 2
Symbol
ago2 Nomenclature History
Previous Names
  • Ago2 (1)
  • eif2c2
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Enables miRNA binding activity and pre-miRNA binding activity. Acts upstream of or within nucleate erythrocyte differentiation and pre-miRNA processing. Predicted to be located in P-body. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in several structures, including eye; fin; integument; intermediate cell mass of mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Orthologous to human AGO2 (argonaute RISC catalytic component 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa196Allele with one point mutationUnknownPremature StopENU
sa23583Allele with one point mutationUnknownSplice SiteENU
sa23584Allele with one point mutationUnknownSplice SiteENU
ya100Allele with one deletionUnknownUnknownzinc finger nuclease
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Sequence Targeting Reagents
No data available
Human Disease
Associated With ago2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Lessel-Kreienkamp syndrome 619149
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Associated With ago2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003100 PAZ domain
Domain IPR003165 Piwi domain
Domain IPR014811 Argonaute, linker 1 domain
Domain IPR032472 Argonaute linker 2 domain
Domain IPR032473 Protein argonaute, Mid domain
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Domain Details Per Protein
Protein Additional Resources Length Argonaute-like, PIWI domain Argonaute, linker 1 domain Argonaute linker 2 domain PAZ domain PAZ domain superfamily Piwi domain Protein argonaute-2 Protein argonaute, Mid domain Protein argonaute, N-terminal Ribonuclease H-like superfamily Ribonuclease H superfamily
UniProtKB:A0A8M3AKD0 InterPro 898
UniProtKB:K4I874 InterPro 873
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ago2-201 (1) Ensembl 2,966 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-351F10
Contained inBACCH211-57N23
EncodesESTwz1283
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Sequences
Orthology
Comparative Orthology
Alliance
Species Symbol Chromosome Accession # Evidence
HumanAGO28
Amino acid sequence comparison (1)
Conserved genome location (synteny) (2)
MouseAgo215
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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