Gene
thpo
- ID
- ZDB-GENE-110510-1
- Name
- thrombopoietin
- Symbol
- thpo Nomenclature History
- Previous Names
-
- TPO (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Acts upstream of or within common myeloid progenitor cell proliferation and thrombocyte differentiation. Predicted to be located in extracellular region. Is expressed in heart; liver; and testis. Used to study thrombocytopenia. Human ortholog(s) of this gene implicated in aplastic anemia; congenital amegakaryocytic thrombocytopenia 2; essential thrombocythemia; thrombocytopenia; and thrombocytosis. Orthologous to human THPO (thrombopoietin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Yang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| szy6 | Allele with one delins | Exon 1 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital amegakaryocytic thrombocytopenia 2 | Alliance | Amegakaryocytic thrombocytopenia, congenital, 2 | 620481 |
| essential thrombocythemia | Alliance | Thrombocythemia 1 | 187950 |
| Thrombocytopenia 9 | 620478 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| thrombocytopenia | thposzy6/szy6; sm9Tg (AB) | standard conditions | Yang et al., 2022 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Erythropoietin/thrombopoietin | Four-helical cytokine-like, core | Thrombopoietin |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9QF65 | InterPro | 141 | |||
| UniProtKB:B5L331 | InterPro | 191 | |||
| UniProtKB:A0A8M6Z2C6 | InterPro | 192 | |||
| UniProtKB:A0AB32U0U6 | InterPro | 163 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-234E14 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001143753 (1) | 576 nt | ||
| Genomic | GenBank:BX296556 (1) | 181230 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z2C6 (1) | 192 aa |
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Kimura, K., Yamamori, S., Hazawa, M., Kobayashi-Sun, J., Kondo, M., Wong, R.W., Kobayashi, I. (2022) Inhibition of canonical Wnt signaling promotes ex vivo maintenance and proliferation of hematopoietic stem cells in zebrafish. Stem cells (Dayton, Ohio). 40(9):831-842
- Yang, L., Wu, L., Meng, P., Zhang, X., Zhao, D., Lin, Q., Zhang, Y. (2022) Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish. Journal of thrombosis and haemostasis : JTH. 20(8):1900-1909
- Chen, X., Teng, M., Zhang, J., Qian, L., Duan, M., Cheng, Y., Zhao, F., Zheng, J., Wang, C. (2020) Tralopyril induces developmental toxicity in zebrafish embryo (Danio rerio) by disrupting the thyroid system and metabolism. The Science of the total environment. 746:141860
- Fu, J., Guo, Y., Wang, M., Yang, L., Han, J., Lee, J.S., Zhou, B. (2020) Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae. Ecotoxicology and environmental safety. 206:111207
- Lee, S., Eghan, K., Lee, J., Yoo, D., Yoon, S., Kim, W.K. (2020) Zebrafish Embryonic Exposure to BPAP and Its Relatively Weak Thyroid Hormone-Disrupting Effects. Toxics. 8(4):
- Liang, Y.Q., Xu, W., Liang, X., Jing, Z., Pan, C.G., Tian, F. (2020) The synthetic progestin norethindrone causes thyroid endocrine disruption in adult zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 236:108819
- Qiao, K., Hu, T., Jiang, Y., Huang, J., Hu, J., Gui, W., Ye, Q., Li, S., Zhu, G. (2020) Crosstalk of cholinergic pathway on thyroid disrupting effects of the insecticide chlorpyrifos in zebrafish (Danio rerio). The Science of the total environment. 757:143769
- Wu, L., Chen, H., Ru, H., Li, Y., Yao, F., Ni, Z., Zhong, L. (2020) Sex-specific effects of triphenyltin chloride (TPT) on thyroid disruption and metabolizing enzymes in adult zebrafish (Danio rerio). Toxicology letters. 331:143-151
- Yao, F., Li, Y., Ru, H., Wu, L., Xiao, Z., Ni, Z., Chen, D., Zhong, L. (2020) Thyroid disruption and developmental toxicity caused by triphenyltin (TPT) in zebrafish embryos/larvae. Toxicology and applied pharmacology. 394:114957
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