Gene
thpo
- ID
- ZDB-GENE-110510-1
- Name
- thrombopoietin
- Symbol
- thpo Nomenclature History
- Previous Names
-
- TPO (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and hormone activity. Acts upstream of or within common myeloid progenitor cell proliferation and thrombocyte differentiation. Predicted to be located in extracellular region. Is expressed in heart; liver; and testis. Used to study thrombocytopenia. Human ortholog(s) of this gene implicated in aplastic anemia; congenital amegakaryocytic thrombocytopenia 2; essential thrombocythemia; thrombocytopenia; and thrombocytosis. Orthologous to human THPO (thrombopoietin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Yang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| szy6 | Allele with one delins | Exon 1 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital amegakaryocytic thrombocytopenia 2 | Alliance | Amegakaryocytic thrombocytopenia, congenital, 2 | 620481 |
| essential thrombocythemia | Alliance | Thrombocythemia 1 | 187950 |
| Thrombocytopenia 9 | 620478 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| thrombocytopenia | thposzy6/szy6; sm9Tg (AB) | standard conditions | Yang et al., 2022 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Erythropoietin/thrombopoietin | Four-helical cytokine-like, core | Thrombopoietin |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9QF65 | InterPro | 141 | |||
| UniProtKB:B5L331 | InterPro | 191 | |||
| UniProtKB:A0A8M6Z2C6 | InterPro | 192 | |||
| UniProtKB:A0AB32U0U6 | InterPro | 163 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-234E14 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001143753 (1) | 576 nt | ||
| Genomic | GenBank:BX296556 (1) | 181230 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z2C6 (1) | 192 aa |
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Kimura, K., Yamamori, S., Hazawa, M., Kobayashi-Sun, J., Kondo, M., Wong, R.W., Kobayashi, I. (2022) Inhibition of canonical Wnt signaling promotes ex vivo maintenance and proliferation of hematopoietic stem cells in zebrafish. Stem cells (Dayton, Ohio). 40(9):831-842
- Yang, L., Wu, L., Meng, P., Zhang, X., Zhao, D., Lin, Q., Zhang, Y. (2022) Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish. Journal of thrombosis and haemostasis : JTH. 20(8):1900-1909
- Chen, X., Teng, M., Zhang, J., Qian, L., Duan, M., Cheng, Y., Zhao, F., Zheng, J., Wang, C. (2020) Tralopyril induces developmental toxicity in zebrafish embryo (Danio rerio) by disrupting the thyroid system and metabolism. The Science of the total environment. 746:141860
- Fu, J., Guo, Y., Wang, M., Yang, L., Han, J., Lee, J.S., Zhou, B. (2020) Bioconcentration of 2,4,6-tribromophenol (TBP) and thyroid endocrine disruption in zebrafish larvae. Ecotoxicology and environmental safety. 206:111207
- Lee, S., Eghan, K., Lee, J., Yoo, D., Yoon, S., Kim, W.K. (2020) Zebrafish Embryonic Exposure to BPAP and Its Relatively Weak Thyroid Hormone-Disrupting Effects. Toxics. 8(4):
- Liang, Y.Q., Xu, W., Liang, X., Jing, Z., Pan, C.G., Tian, F. (2020) The synthetic progestin norethindrone causes thyroid endocrine disruption in adult zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 236:108819
- Qiao, K., Hu, T., Jiang, Y., Huang, J., Hu, J., Gui, W., Ye, Q., Li, S., Zhu, G. (2020) Crosstalk of cholinergic pathway on thyroid disrupting effects of the insecticide chlorpyrifos in zebrafish (Danio rerio). The Science of the total environment. 757:143769
- Wu, L., Chen, H., Ru, H., Li, Y., Yao, F., Ni, Z., Zhong, L. (2020) Sex-specific effects of triphenyltin chloride (TPT) on thyroid disruption and metabolizing enzymes in adult zebrafish (Danio rerio). Toxicology letters. 331:143-151
- Yao, F., Li, Y., Ru, H., Wu, L., Xiao, Z., Ni, Z., Chen, D., Zhong, L. (2020) Thyroid disruption and developmental toxicity caused by triphenyltin (TPT) in zebrafish embryos/larvae. Toxicology and applied pharmacology. 394:114957
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