Gene

oat

ID

ZDB-GENE-110411-148

Name

ornithine aminotransferase

Symbol

oat Nomenclature History

Previous Names

si:dkey-68e16.4

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable identical protein binding activity; ornithine aminotransferase activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-arginine catabolic process to L-glutamate and L-arginine catabolic process to proline via ornithine. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zielonka et al., 2018

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With oat Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
gyrate atrophy	Alliance	Gyrate atrophy of choroid and retina with or without ornithinemia	258870

Associated With oat Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR049704	Aminotransferases class-III pyridoxal-phosphate attachment site
Family	IPR005814	Aminotransferase class-III
Family	IPR010164	Ornithine aminotransferase
Family	IPR050103	Class-III Pyridoxal-phosphate-dependent Aminotransferase
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase