Gene
ccl25b
- ID
- ZDB-GENE-110222-2
- Name
- chemokine (C-C motif) ligand 25b
- Symbol
- ccl25b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables chemokine activity. Acts upstream of or within several processes, including lymphoid lineage cell migration into thymus; regulation of hematopoietic stem cell migration; and regulation of hematopoietic stem cell proliferation. Predicted to be located in extracellular space. Is expressed in several structures, including blood vessel; head; hematopoietic system; immune system; and spinal cord. Orthologous to human CCL25 (C-C motif chemokine ligand 25).
- Genome Resources
- Note
-
I-Na Lu et al. (120807-5) suggest orthology to CCL21 based on AA similarity and CL with human Chr 9.
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Xue et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-ccl25b | N/A | (2) |
MO2-ccl25b | N/A | Xue et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Chemokine beta/gamma/delta | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily |
---|---|---|---|---|---|
UniProtKB:F1QBE9 | InterPro | 106 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ccl25b-201
(1)
|
Ensembl | 806 nt | ||
mRNA |
ccl25b-203
(1)
|
Ensembl | 3,370 nt | ||
ncRNA |
ccl25b-002
(1)
|
Ensembl | 883 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-224J12 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001200035 (1) | 821 nt | ||
Genomic | GenBank:AL840638 (1) | 177617 nt | ||
Polypeptide | UniProtKB:F1QBE9 (1) | 106 aa |
- El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029
- Jim, K.K., Aprianto, R., Koning, R., Domenech, A., Kurushima, J., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Bitter, W., Veening, J.W. (2022) Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq. Cell Reports. 41:111851111851
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Sun, J., Peterson, E.A., Wang, A.Z., Ou, J., Smith, K.E., Poss, K.D., Wang, J. (2022) hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration. Circulation. 146(1):48-63
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Tu, J., Liu, X., Jia, H., Reilly, J., Yu, S., Cai, C., Liu, F., Lv, Y., Huang, Y., Lu, Z., Han, S., Jiang, T., Shu, X., Wu, X., Tang, Z., Lu, Q., Liu, M. (2020) The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(9):11997-12008
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Yang, Y., Li, B., Zhang, X., Zhao, Q., Lou, X. (2019) The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling. Developmental Biology. 446(2):142-150
- Anbalagan, S., Gordon, L., Blechman, J., Matsuoka, R.L., Rajamannar, P., Wircer, E., Biran, J., Reuveny, A., Leshkowitz, D., Stainier, D.Y.R., Levkowitz, G. (2018) Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces. Developmental Cell. 47(6):711-726.e5
- Liu, Z.Z., Wang, Z.L., Choi, T.I., Huang, W.T., Wang, H.T., Han, Y.Y., Zhu, L.Y., Kim, H.T., Choi, J.H., Lee, J.S., Kim, H.G., Zhao, J., Chen, Y., Lu, Z., Tian, X.L., Pan, B.X., Li, B.M., Kim, C.H., Xu, H. (2018) Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish. The American journal of pathology. 188(4):1043-1058
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