Gene
p2ry12
- ID
- ZDB-GENE-110208-4
- Name
- purinergic receptor P2Y12
- Symbol
- p2ry12 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Acts upstream of or within microglial cell activation and regulation of primitive erythrocyte differentiation. Predicted to be located in plasma membrane. Is expressed in axial blood vessel; head; and hematopoietic system. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sih3 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-p2ry12 | Chia et al., 2019 | |
| CRISPR2-p2ry12 | Li et al., 2020 | |
| MO1-p2ry12 | N/A | Sieger et al., 2012 |
| MO2-p2ry12 | N/A | Sieger et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| platelet-type bleeding disorder 8 | Alliance | Bleeding disorder, platelet-type, 8 | 609821 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | P2Y12 purinoceptor |
|---|---|---|---|---|---|
| UniProtKB:E7F2G6 | InterPro | 345 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
p2ry12-201
(1)
|
Ensembl | 1,308 nt | ||
| mRNA |
p2ry12-202
(1)
|
Ensembl | 1,371 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(p2ry12:p2ry12-GFP) |
|
|
| 1 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-64E16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001308557 (1) | 1308 nt | ||
| Genomic | GenBank:CU571333 (2) | 118734 nt | ||
| Polypeptide | UniProtKB:E7F2G6 (1) | 345 aa |
- Marchese, M., Bernardi, S., Ogi, A., Licitra, R., Silvi, G., Mero, S., Galatolo, D., Gammaldi, N., Doccini, S., Ratto, G.M., Rapposelli, S., Neuhauss, S.C.F., Zang, J., Rocchiccioli, S., Michelucci, E., Ceccherini, E., Santorelli, F.M. (2024) Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model. Neurobiology of disease. 197:106536
- Song, P., Parsana, D., Singh, R., Pollock, L.M., Anand-Apte, B., Perkins, B.D. (2024) Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage. Scientific Reports. 14:2014620146
- Zhao, L., Wang, L.F., Wang, Y.C., Liu, A., Xiao, Q.W., Hu, M.C., Sun, M.Z., Hao, H.Y., Gao, Q., Zhao, X., Chen, D.Y. (2024) Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish. Cell biology and toxicology. 40:3636
- Della Vecchia, S., Ogi, A., Licitra, R., Abramo, F., Nardi, G., Mero, S., Landi, S., Battini, R., Sicca, F., Ratto, G.M., Santorelli, F.M., Marchese, M. (2022) Trehalose Treatment in Zebrafish Model of Lafora Disease. International Journal of Molecular Sciences. 23(12)
- Iribarne, M., Hyde, D.R. (2022) Different inflammation responses modulate Müller glia proliferation in the acute or chronically damaged zebrafish retina. Frontiers in cell and developmental biology. 10:892271
- Lou, L., Yu, T., Dai, Y., Zhao, S., Feng, S., Xu, J., Wen, Z. (2022) Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 119:e2203273119
- Rovira, M., Miserocchi, M., Montanari, A., Hammou, L., Chomette, L., Pozo, J., Imbault, V., Bisteau, X., Wittamer, V. (2022) Zebrafish Galectin 3 binding protein (Lgals3bp) is the target antigen of the microglial 4C4 monoclonal antibody. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(3):400-414
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Zhao, F., He, J., Tang, J., Cui, N., Shi, Y., Li, Z., Liu, S., Wang, Y., Ma, M., Zhao, C., Luo, L., Li, L. (2022) Brain milieu induces early microglial maturation through the BAX-Notch axis. Nature communications. 13:6117
- Cavone, L., McCann, T., Drake, L.K., Aguzzi, E.A., Oprişoreanu, A.M., Pedersen, E., Sandi, S., Selvarajah, J., Tsarouchas, T.M., Wehner, D., Keatinge, M., Mysiak, K.S., Henderson, B.E.P., Dobie, R., Henderson, N.C., Becker, T., Becker, C.G. (2021) A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord. Developmental Cell. 56(11):1617-1630.e6
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