Gene

col4a6

ID
ZDB-GENE-101001-2
Name
collagen, type IV, alpha 6
Symbol
col4a6 Nomenclature History
Previous Names
  • im:7147757
  • shiomaneki (1)
  • sio
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within axon extension involved in axon guidance and basement membrane organization. Predicted to be located in basement membrane and extracellular region. Predicted to be part of collagen type IV trimer. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; head; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in X-linked deafness 6. Orthologous to human COL4A6 (collagen type IV alpha 6 chain).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la026127TgTransgenic insertionUnknownUnknownDNA
rk18Allele with one point mutationDonor Splice Site of Intron 42Unknownnot specified
sa7085Allele with one point mutationUnknownSplice SiteENU
sa34180Allele with one point mutationUnknownSplice SiteENU
sa41014Allele with one point mutationUnknownSplice SiteENU
sa41015Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With col4a6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
X-linked deafness 6 Alliance ?Deafness, X-linked 6 300914
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Associated With col4a6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001442 Collagen IV, non-collagenous
Family IPR050149 Collagen superfamily
Homologous_superfamily IPR016187 C-type lectin fold
Homologous_superfamily IPR036954 Collagen IV, non-collagenous domain superfamily
Repeat IPR008160 Collagen triple helix repeat
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Domain Details Per Protein
Protein Additional Resources Length Collagen IV, non-collagenous Collagen IV, non-collagenous domain superfamily Collagen superfamily Collagen triple helix repeat C-type lectin fold
UniProtKB:A0A8M9QD06 InterPro 1688
UniProtKB:A0A8M3B4D5 InterPro 1686
UniProtKB:A0A8M6Z091 InterPro 1714
UniProtKB:A0A8M6Z7E0 InterPro 1717
UniProtKB:A0A8M6Z1T7 InterPro 1700
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 7
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA col4a6-201 (1) Ensembl 5,145 nt
mRNA col4a6-202 (1) Ensembl 8,255 nt
mRNA col4a6-203 (1) Ensembl 5,001 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
EncodesESTIMAGE:7147757ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCOL4A6X
Amino acid sequence comparison (3)
Conserved genome location (synteny) (3)
MouseCol4a6X
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
Citations
1 - 10 of 14
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