Gene
macf1b
- ID
- ZDB-GENE-100922-36
- Name
- microtubule actin crosslinking factor 1b
- Symbol
- macf1b Nomenclature History
- Previous Names
-
- si:dkey-283b15.3
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be involved in intermediate filament cytoskeleton organization and wound healing. Predicted to be located in cytoskeleton and plasma membrane. Predicted to be active in cytoplasm and membrane. Predicted to colocalize with intermediate filament. Is expressed in macula.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Antonellis et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12044 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13927 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36031 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42652 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42653 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42654 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45562 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | GAR domain | GAR domain superfamily | Plakin | Spectrin/alpha-actinin | Spectrin repeat |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7UTC3 | InterPro | 2086 | ||||||||
| UniProtKB:A0AB32T2U0 | InterPro | 1983 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
macf1b-201
(1)
|
Ensembl | 725 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-283B15 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_690777 (1) | 11090 nt | ||
| Genomic | GenBank:CR848788 (1) | 189441 nt | ||
| Polypeptide | UniProtKB:A0A8N7UTC3 (1) | 2086 aa |
No data available
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Antonellis, P.J., Pollock, L.M., Chou, S.W., Hassan, A., Geng, R., Chen, X., Fuchs, E., Alagramam, K.N., Auer, M., and McDermott, B.M. (2014) ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(1):305-312
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