Gene
kif26ab
- ID
- ZDB-GENE-100716-6
- Name
- kinesin family member 26Ab
- Symbol
- kif26ab Nomenclature History
- Previous Names
-
- id:ibd5051
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within germ cell development. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including germ ring; lateral mesoderm; notochord; oocyte; and tail bud. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tao et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1305 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8994 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13169 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23177 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23178 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36518 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36519 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36520 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complex cortical dysplasia with other brain malformations 11 | Alliance | Cortical dysplasia, complex, with other brain malformations 11 | 620156 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B5F7 | InterPro | 1715 | ||||
| UniProtKB:A0A8M2B5W9 | InterPro | 2023 | ||||
| UniProtKB:A0A8M2B5X7 | InterPro | 2049 | ||||
| UniProtKB:A0A8M2B5I5 | InterPro | 1744 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kif26ab-201
(1)
|
Ensembl | 8,243 nt | ||
| ncRNA |
kif26ab-002
(1)
|
Ensembl | 777 nt | ||
| ncRNA |
kif26ab-003
(1)
|
Ensembl | 560 nt | ||
| ncRNA |
kif26ab-004
(1)
|
Ensembl | 516 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-184P2 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-99F11 | ZFIN Curated Data | |
| Encodes | EST | ibd5051 | ||
| Encodes | EST | wz12137 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005158960 (1) | 8461 nt | ||
| Genomic | GenBank:BX323446 (2) | 184290 nt | ||
| Polypeptide | UniProtKB:A0A8M2B5X7 (1) | 2049 aa |
- Comparative Orthology
- Alliance
- Tao, B., Hu, H., Chen, J., Chen, L., Luo, D., Sun, Y., Ge, F., Zhu, Z., Trudeau, V.L., Hu, W. (2022) Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. EMBO reports. 23(6):e54387
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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