Gene
peak1
- ID
- ZDB-GENE-100422-1
- Name
- pseudopodium-enriched atypical kinase 1
- Symbol
- peak1 Nomenclature History
- Previous Names
-
- gb:eh551459 (1)
- si:dkey-7n16.1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Acts upstream of or within angiogenesis and regulation of blood vessel endothelial cell migration. Predicted to be located in actin cytoskeleton and focal adhesion. Orthologous to human PEAK1 (pseudopodium enriched atypical kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Wang et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8851 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24602 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32513 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44230 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf2170 | Allele with one deletion | Unknown | Frameshift | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-peak1 | N/A | Wang et al., 2018 |
| MO2-peak1 | N/A | Wang et al., 2018 |
| TALEN1-peak1 | Wang et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Mitochondrial Quality Control and Scaffold Kinases | Protein kinase domain | Protein kinase-like domain superfamily | Tyrosine-protein kinase, active site |
|---|---|---|---|---|---|---|
| UniProtKB:X1WGC5 | InterPro | 1725 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-7N16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001921567 (1) | 5866 nt | ||
| Genomic | GenBank:BX005076 (1) | 206504 nt | ||
| Polypeptide | UniProtKB:X1WGC5 (1) | 1725 aa |
- Wang, H., Lapek, J., Fujimura, K., Strnadel, J., Liu, B., Gonzalez, D.J., Zhang, W., Watson, F., Yu, V., Liu, C., Melo, C.M., Miller, Y.I., Elliott, K.C., Cheresh, D.A., Klemke, R.L. (2018) Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell discovery. 4:26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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