Gene

adrb2a

ID
ZDB-GENE-100414-3
Name
adrenoceptor beta 2, surface a
Symbol
adrb2a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable beta2-adrenergic receptor activity and norepinephrine binding activity. Acts upstream of or within pigmentation and regulation of heart rate. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
u511Allele with one deletionUnknownUnknownCRISPR
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-adrb2aÖzcan et al., 2020
MO1-adrb2aN/A (4)
1 - 2 of 2
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Human Disease
Associated With adrb2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Beta-2-adrenoreceptor agonist, reduced response to
1 - 1 of 1
Associated With adrb2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR002233 Adrenoceptor family
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length Adrenoceptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:I7GPU6 InterPro 405
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 14
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA adrb2a-201 (1) Ensembl 5,042 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-164F1ZFIN Curated Data
1 - 1 of 1
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanADRB25
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseAdrb218
Amino acid sequence comparison (1)
Citations
1 - 10 of 22
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