Gene
adrb2a
- ID
- ZDB-GENE-100414-3
- Name
- adrenoceptor beta 2, surface a
- Symbol
- adrb2a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable beta2-adrenergic receptor activity and norepinephrine binding activity. Acts upstream of or within pigmentation and regulation of heart rate. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| u511 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adrb2a | Özcan et al., 2020 | |
| MO1-adrb2a | N/A | (4) |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Beta-2-adrenoreceptor agonist, reduced response to |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Adrenoceptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:I7GPU6 | InterPro | 405 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adrb2a-201
(1)
|
Ensembl | 5,042 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-164F1 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001102652 (1) | 1218 nt | ||
| Genomic | GenBank:FP103054 (2) | 72781 nt | ||
| Polypeptide | UniProtKB:I7GPU6 (1) | 405 aa |
- Joyce, W., Pan, Y.K., Garvey, K., Saxena, V., Perry, S.F. (2022) The regulation of heart rate following genetic deletion of the ß1 adrenergic receptor in larval zebrafish. Acta physiologica (Oxford, England). 235(4):e13849
- Kumar, N., Zhao, H.N., Awoyemi, O., Kolodziej, E.P., Crago, J. (2021) Toxicity Testing of Effluent-Dominated Stream Using Predictive Molecular-Level Toxicity Signatures Based on High-Resolution Mass Spectrometry: A Case Study of the Lubbock Canyon Lake System. Environmental science & technology. 55(5):3070-3080
- Li, W., Shenkar, R., Detter, M.R., Moore, T., Benavides, C.R., Lightle, R., Girard, R., Hobson, N., Cao, Y., Li, Y., Griffin, E., Gallione, C., Zabramski, J.M., Ginsberg, M.H., Marchuk, D.A., Awad, I.A. (2020) Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism. The Journal of Clinical Investigation. 131(3)
- Özcan, G.G., Lim, S., Leighton, P., Allison, W.T., Rihel, J. (2020) Sleep is bi-directionally modified by amyloid beta oligomers. eLIFE. 9:
- Chen, L., Wang, Y., Giesy, J.P., Chen, F., Shi, T., Chen, J., Xie, P. (2018) Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish. Environmental pollution (Barking, Essex : 1987). 241:540-548
- Feng, X., Yu, X., Fu, B., Wang, X., Liu, H., Pang, M., Tong, J. (2018) A high-resolution genetic linkage map and QTL fine mapping for growth-related traits and sex in the Yangtze River common carp (Cyprinus carpio haematopterus). BMC Genomics. 19:230
- Pandey, S., Shekhar, K., Regev, A., Schier, A.F. (2018) Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Current biology : CB. 28(7):1052-1065.e7
- Kossack, M., Hein, S., Juergensen, L., Siragusa, M., Benz, A., Katus, H.A., Most, P., Hassel, D. (2017) Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation. Journal of Molecular and Cellular Cardiology. 108:95-105
- Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130
- Zhang, L., Jin, Y., Han, Z., Liu, H., Shi, L., Hua, X., A Doering, J., Tang, S., P Giesy, J., Yu, H. (2017) INTEGRATED IN SILICO AND IN VIVO APPROACHES TO INVESTIGATE EFFECTS OF BDE-99 MEDIATED BY THE NUCLEAR RECEPTORS ON DEVELOPING ZEBRAFISH. Environmental toxicology and chemistry. 37(3):780-787
1 - 10 of 22
Show