Gene
git1
- ID
- ZDB-GENE-100408-5
- Name
- G protein-coupled receptor kinase interacting ArfGAP 1
- Symbol
- git1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity and small GTPase binding activity. Acts upstream of or within angiogenesis. Predicted to be active in cytosol; neuron projection; and postsynapse. Is expressed in head. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Liu et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Liu et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35903 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-git1 | N/A | Liu et al., 2012 |
| MO2-git1 | N/A | Liu et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001164 | Arf GTPase activating protein |
| Domain | IPR013724 | GIT, Spa2 homology (SHD) domain |
| Domain | IPR022018 | ARF GTPase-activating protein GIT1, C-terminal |
| Domain | IPR032352 | Arf GTPase-activating protein GIT1/2, coiled-coil domain |
| Family | IPR047161 | ARF GTPase-activating protein Git-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | ArfGAP domain superfamily | ARFGAP/RecO-like zinc finger | Arf GTPase activating protein | Arf GTPase-activating protein GIT1/2, coiled-coil domain | ARF GTPase-activating protein GIT1, C-terminal | ARF GTPase-activating protein Git-like | GIT, Spa2 homology (SHD) domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AHJ1 | InterPro | 667 | |||||||||
| UniProtKB:A0A0R4IPR8 | InterPro | 761 | |||||||||
| UniProtKB:E7FAZ2 | InterPro | 752 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-190A13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005157670 (1) | 5000 nt | ||
| Genomic | GenBank:CU570681 (2) | 116371 nt | ||
| Polypeptide | UniProtKB:A0A0R4IPR8 (1) | 761 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, J., Zeng, L., Kennedy, R.M., Gruenig, N.M., and Childs, S.J. (2012) betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8. Developmental Biology. 363(1):95-105
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