Gene
tnfaip3
- ID
- ZDB-GENE-100212-2
- Name
- tumor necrosis factor, alpha-induced protein 3
- Symbol
- tnfaip3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| dgi4 | Allele with one deletion | Exon 2 | Premature Stop | not specified | |
| sa10832 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22193 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22194 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35393 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35394 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial Behcet-like autoinflammatory syndrome | Alliance | Autoinflammatory syndrome, familial, Behcet-like 1 | 616744 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | OTU domain | OTU Domain-Containing Deubiquitinase | Zinc finger, A20-type |
|---|---|---|---|---|---|
| UniProtKB:A0A8N7T672 | InterPro | 762 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfaip3-201
(1)
|
Ensembl | 2,253 nt | ||
| mRNA |
tnfaip3-202
(1)
|
Ensembl | 2,271 nt | ||
| mRNA |
tnfaip3-203
(1)
|
Ensembl | 2,193 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-58K20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-274C22 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_687830 (1) | 2966 nt | ||
| Genomic | GenBank:BX323887 (2) | 134841 nt | ||
| Polypeptide | UniProtKB:A0A8N7T672 (1) | 762 aa |
- Cultrone, D., Zammit, N.W., Self, E., Postert, B., Han, J.Z.R., Bailey, J., Warren, J., Croucher, D.R., Kikuchi, K., Bogdanovic, O., Chtanova, T., Hesselson, D., Grey, S.T. (2020) A zebrafish functional genomics model to investigate the role of human A20 variants in vivo. Scientific Reports. 10:19085
- Murdoch, C.C., Espenschied, S.T., Matty, M.A., Mueller, O., Tobin, D.M., Rawls, J.F. (2019) Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization. PLoS pathogens. 15:e1007381
- Tse, W.K.F. (2017) Importance of deubiquitinases in zebrafish craniofacial development. Biochemical and Biophysical Research Communications. 487(4):813-819
- Fredericksen, F., Villalba, M., Olavarría, V.H. (2016) Characterization of bovine A20 gene: Expression mediated by NF-κB pathway in MDBK cells infected with bovine viral diarrhea virus-1. Gene. 581(2):117-29
- Hulpiau, P., Driege, Y., Staal, J., Beyaert, R. (2016) MALT1 is not alone after all: identification of novel paracaspases. Cellular and molecular life sciences : CMLS. 73(5):1103-16
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Oehlers, S.H., Flores, M.V., Hall, C.J., Swift, S., Crosier, K.E., and Crosier, P.S. (2011) The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Disease models & mechanisms. 4(6):832-41
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
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