Gene

tnfaip3

ID
ZDB-GENE-100212-2
Name
tumor necrosis factor, alpha-induced protein 3
Symbol
tnfaip3 Nomenclature History
Previous Names
  • a20 (1)
  • si:ch211-274c22.6 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
dgi4Allele with one deletionExon 2Premature Stopnot specified
sa10832Allele with one point mutationUnknownPremature StopENU
sa22193Allele with one point mutationUnknownPremature StopENU
sa22194Allele with one point mutationUnknownPremature StopENU
sa35393Allele with one point mutationUnknownPremature StopENU
sa35394Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-tnfaip3N/A (2)
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Human Disease
Associated With tnfaip3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial Behcet-like autoinflammatory syndrome Alliance Autoinflammatory syndrome, familial, Behcet-like 1 616744
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Associated With tnfaip3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002653 Zinc finger, A20-type
Domain IPR003323 OTU domain
Family IPR051346 OTU Domain-Containing Deubiquitinase
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Domain Details Per Protein
Protein Additional Resources Length OTU domain OTU Domain-Containing Deubiquitinase Zinc finger, A20-type
UniProtKB:A0A8N7T672 InterPro 762
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tnfaip3-201 (1) Ensembl 2,253 nt
mRNA tnfaip3-202 (1) Ensembl 2,271 nt
mRNA tnfaip3-203 (1) Ensembl 2,193 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-58K20ZFIN Curated Data
Contained inBACCH211-274C22
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTNFAIP36
Conserved genome location (synteny) (1)
Amino acid sequence comparison (3)
MouseTnfaip310
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
1 - 9 of 9
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