Gene
nox5
- ID
- ZDB-GENE-091120-9
- Name
- NADPH oxidase, EF-hand calcium binding domain 5
- Symbol
- nox5 Nomenclature History
- Previous Names
-
- si:ch1073-365g6.1
- zmp:0000000874 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within neutrophil migration. Predicted to be located in membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Is expressed in nervous system. Orthologous to human NOX5 (NADPH oxidase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Weaver et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9962 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10707 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19358 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24610 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| umc402 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| umc408 | Allele with one delins | Exon 4 | Unknown | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nox5 | Weaver et al., 2018 | |
| CRISPR2-nox5 | Weaver et al., 2018 | |
| CRISPR3-nox5 | Zebrafish Nomenclature Committee | |
| CRISPR4-nox5 | Martínez-Morcillo et al., 2021 | |
| CRISPR5-nox5 | (2) | |
| MO1-nox5 | N/A | Yan et al., 2014 |
| MO2-nox5 | N/A | Wang et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome b245, heavy chain | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | FAD-binding 8 | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Ferric reductase, NAD binding domain | Ferric reductase transmembrane component-like domain | Respiratory burst oxidase/Ferric reductase | Riboflavin synthase-like beta-barrel |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YWR9 | InterPro | 775 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-365G6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017354320 (1) | |||
| Genomic | GenBank:CU467844 (1) | 28527 nt | ||
| Polypeptide | UniProtKB:A0A8M6YWR9 (1) | 775 aa |
- Comparative Orthology
- Alliance
- Chopra, K., Folkmanaitė, M., Stockdale, L., Shathish, V., Ishibashi, S., Bergin, R., Amich, J., Amaya, E. (2023) Duox is the primary NADPH oxidase responsible for ROS production during adult caudal fin regeneration in zebrafish. iScience. 26:106147106147
- Thauvin, M., de Sousa, R.M., Alves, M., Volovitch, M., Vriz, S., Rampon, C. (2022) An early Shh-H2O2 reciprocal regulatory interaction controls the regenerative program during zebrafish fin regeneration. Journal of Cell Science. 135(6):
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Martínez-Morcillo, F.J., Cantón-Sandoval, J., Martínez-Navarro, F.J., Cabas, I., Martínez-Vicente, I., Armistead, J., Hatzold, J., López-Muñoz, A., Martínez-Menchón, T., Corbalán-Vélez, R., Lacal, J., Hammerschmidt, M., García-Borrón, J.C., García-Ayala, A., Cayuela, M.L., Pérez-Oliva, A.B., García-Moreno, D., Mulero, V. (2021) NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. PLoS Biology. 19:e3001455
- Wang, J., Xiao, J., Meng, X., Chu, X., Zhuansun, D.D., Xiong, B., Feng, J. (2021) NOX5 is expressed aberrantly but not a critical pathogenetic gene in Hirschsprung disease. BMC pediatrics. 21:153
- Yin, H.M., Yan, L.F., Liu, Q., Peng, Z., Zhang, C.Y., Xia, Y., Su, D., Gu, A.H., Zhou, Y. (2020) Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science advances. 6:eaay9466
- Park, K.H., Kim, S.H. (2019) Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 117:109179
- Park, K.H., Ye, Z.W., Zhang, J., Kim, S.H. (2019) Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish. Zebrafish. 16(6):497-504
- Weaver, C.J., Terzi, A., Roeder, H., Gurol, T., Deng, Q., Fai Leung, Y., Suter, D.M. (2018) nox2/cybb deficiency affects zebrafish retinotectal connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(26):5854-5871
- Coppola, U., Annona, G., D'Aniello, S., Ristoratore, F. (2016) Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evolutionary Biology. 16:26
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