Gene

aifm5

ID

ZDB-GENE-091118-96

Name

apoptosis inducing factor mitochondria associated 5

Symbol

aifm5 Nomenclature History

Previous Names

si:ch211-274p24.3

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable oxidoreductase activity, acting on NAD(P)H.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Leid et al., 2023

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa15498	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa30725	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With aifm5 Human Ortholog

No data available

Associated With aifm5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017941	Rieske [2Fe-2S] iron-sulphur domain
Domain	IPR023753	FAD/NAD(P)-binding domain
Domain	IPR028202	Reductase, C-terminal
Family	IPR050446	FAD-dependent Oxidoreductases and Apoptosis Regulators
Homologous_superfamily	IPR016156	FAD/NAD-linked reductase, dimerisation domain superfamily

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Domain Details Per Protein

Protein	Additional Resources	Length	FAD-dependent Oxidoreductases and Apoptosis Regulators	FAD/NAD-linked reductase, dimerisation domain superfamily	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain superfamily	Reductase, C-terminal	Rieske [2Fe-2S] iron-sulphur domain	Rieske [2Fe-2S] iron-sulphur domain superfamily
UniProtKB:E7F3F1	InterPro	543

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 21

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	aifm5-201 (1) Ensembl	Ensembl		1,632 nt	Select Tool ZFIN BLAST
mRNA	aifm5-202 (1) Ensembl	Ensembl		1,901 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-274P24	AL929193	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_001920876 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:AL929193	159094 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7F3F1 (1)	543 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

No data available

Citations

Include unpublished citations

Leid, J., Gray, R., Rakita, P., Koenig, A.L., Tripathy, R., Fitzpatrick, J.A.J., Kaufman, C., Solnica-Krezel, L., Lavine, K.J. (2023) Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism. Biology Open. 12(7):

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