Gene
znf385c
- ID
- ZDB-GENE-091112-1
- Name
- zinc finger protein 385C
- Symbol
- znf385c Nomenclature History
- Previous Names
-
- si:dkey-26l17.1
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable nucleic acid binding activity and zinc ion binding activity. Located in nucleus. Is expressed in Purkinje cell. Orthologous to human ZNF385C (zinc finger protein 385C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Takeuchi et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Hochgreb-Hägele et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct39aGt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13207 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26032 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa33127 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-znf385c | N/A | Hochgreb-Hägele et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Matrin/U1-C, C2H2-type zinc finger | Matrin/U1-C-like, C2H2-type zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger protein 385 |
|---|---|---|---|---|---|---|---|
| UniProtKB:E9QJ33 | InterPro | 459 | |||||
| UniProtKB:A0A8M1QV45 | InterPro | 460 | |||||
| UniProtKB:A0A8M2BB30 | InterPro | 446 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
znf385c-201
(1)
|
Ensembl | 1,527 nt | ||
| mRNA |
znf385c-202
(1)
|
Ensembl | 1,611 nt | ||
| mRNA |
znf385c-203
(1)
|
Ensembl | 1,033 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-26L17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001921873 (1) | 4887 nt | ||
| Genomic | GenBank:BX901973 (1) | 226081 nt | ||
| Polypeptide | UniProtKB:A0A8M1QV45 (1) | 460 aa |
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hochgreb-Hägele, T., Koo, D.E., Bronner, M.E. (2015) Znf385C mediates a novel p53-dependent transcriptional switch to control timing of facial bone formation. Developmental Biology. 400(1):23-32
- Cuello, S., Ximénez-Embún, P., Ruppen, I., Schonthaler, H.B., Ashman, K., Madrid, Y., Luque-Garcia, J.L., and Cámara, C. (2012) Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. The Analyst. 137(22):5302-5311
- Trinh, A., Hochgreb, T., Graham, M., Wu, D., Ruf-Zamojski, F., Jayasena, C.S., Saxena, A., Hawk, R., Gonzalez-Serricchio, A., Dixson, A., Chow, E., Gonzales, C., Leung, H.Y., Solomon, I., Bronner-Fraser, M., Megason, S.G., and Fraser, S.E. (2011) A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes & Development. 25(21):2306-20
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