Gene

nlgn1

ID
ZDB-GENE-090918-1
Name
neuroligin 1
Symbol
nlgn1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable neurexin family protein binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in plasma membrane and synapse. Predicted to be active in postsynaptic specialization membrane. Is expressed in several structures, including brain; cardiovascular system; eye; gonad; and swim bladder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN1 (neuroligin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
fh309Allele with one point mutationUnknownUnknownENU
fh310Allele with one point mutationUnknownUnknownENU
nlgn1_unrecoveredAllele with one point mutationUnknownUnknownENU
sa35027Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-nlgn1
    (2)
    MO1-nlgn1N/ARissone et al., 2012
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    Human Disease
    Associated With nlgn1 Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Autism, susceptibility to, 20} 618830
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    Associated With nlgn1 Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Conserved_site IPR019819 Carboxylesterase type B, conserved site
    Domain IPR002018 Carboxylesterase, type B
    Family IPR000460 Neuroligin
    Family IPR051093 Neuroligin and Bile salt-activated lipase
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
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    Domain Details Per Protein
    Protein Additional Resources Length Alpha/Beta hydrolase fold Carboxylesterase, type B Carboxylesterase type B, conserved site Neuroligin Neuroligin and Bile salt-activated lipase
    UniProtKB:A0A8M6Z1K4 InterPro 847
    UniProtKB:D2X2F9 InterPro 867
    UniProtKB:A0A8M6Z363 InterPro 827
    UniProtKB:B6EUL6 InterPro 847
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    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 11
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA nlgn1-201 (1) Ensembl 2,544 nt
    mRNA nlgn1-202 (1) Ensembl 2,203 nt
    mRNA nlgn1-203 (1) Ensembl 153 nt
    mRNA nlgn1-204 (1) Ensembl 2,604 nt
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    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    No data available
    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inBACCH211-28A12ZFIN Curated Data
    Contained inBACCH211-119C22ZFIN Curated Data
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanNLGN13
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (3)
    MouseNlgn13
    Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Citations
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