Gene
nlgn1
- ID
- ZDB-GENE-090918-1
- Name
- neuroligin 1
- Symbol
- nlgn1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable neurexin family protein binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in plasma membrane and synapse. Predicted to be active in postsynaptic specialization membrane. Is expressed in several structures, including brain; cardiovascular system; eye; gonad; and swim bladder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN1 (neuroligin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
fh309 | Allele with one point mutation | Unknown | Unknown | ENU | |
fh310 | Allele with one point mutation | Unknown | Unknown | ENU | |
nlgn1_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
sa35027 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-nlgn1 | (2) | |
MO1-nlgn1 | N/A | Rissone et al., 2012 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
{Autism, susceptibility to, 20} | 618830 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Carboxylesterase, type B | Carboxylesterase type B, conserved site | Neuroligin | Neuroligin and Bile salt-activated lipase |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M6Z1K4 | InterPro | 847 | |||||
UniProtKB:D2X2F9 | InterPro | 867 | |||||
UniProtKB:A0A8M6Z363 | InterPro | 827 | |||||
UniProtKB:B6EUL6 | InterPro | 847 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-28A12 | ZFIN Curated Data | |
Contained in | BAC | CH211-119C22 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001142265 (1) | 2544 nt | ||
Genomic | GenBank:LO017853 (1) | 167714 nt | ||
Polypeptide | UniProtKB:D2X2F9 (1) | 867 aa |
- Eghan, K., Lee, S., Yoo, D., Kim, W.K. (2025) 2-Ethylhexanol induces autism-like neurobehavior and neurodevelopmental disorders in zebrafish. Journal of hazardous materials. 488:137469137469
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Kareklas, K., Teles, M.C., Dreosti, E., Oliveira, R.F. (2023) Autism-associated gene shank3 is necessary for social contagion in zebrafish. Molecular autism. 14:2323
- Fu, S., Tan, R., Feng, Y., Yu, P., Mo, Y., Xiao, W., Wang, S., Zhang, J. (2022) N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway. Ecotoxicology and environmental safety. 239:113674
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Henríquez Martínez, A., Ávila, L.C., Pulido, M.A., Ardila, Y.A., Akle, V., Bloch, N.I. (2022) Age-Dependent Effects of Chronic Stress on Zebrafish Behavior and Regeneration. Frontiers in Physiology. 13:856778
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Shen, C., Zhou, Y., Tang, C., He, C., Zuo, Z. (2020) Developmental exposure to mepanipyrim induces locomotor hyperactivity in zebrafish (Danio rerio) larvae. Chemosphere. 256:127106
- Dwivedi, S., Medishetti, R., Rani, R., Sevilimedu, A., Kulkarni, P., Yogeeswari, P. (2019) Larval zebrafish model for studying the effects of valproic acid on neurodevelopment: An approach towards modeling autism. Journal of Pharmacological and Toxicological Methods. 95:56-65
- Hughes, A.N., Appel, B. (2019) Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. Nature communications. 10:4125
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