Gene
slc2a1b
- ID
- ZDB-GENE-090915-1
- Name
- solute carrier family 2 member 1b
- Symbol
- slc2a1b Nomenclature History
- Previous Names
-
- si:dkey-92f12.1
- zglut1a (2)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables D-glucose transmembrane transporter activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including bone tissue; heart; liver; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in childhood absence epilepsy; glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025620Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1752 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7048 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20811 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc2a1b | LaCoursiere et al., 2024 | |
| CRISPR2-slc2a1b | LaCoursiere et al., 2024 | |
| MO1-slc2a1b | N/A | Tseng et al., 2011 |
| MO2-slc2a1b | N/A | Delcourt et al., 2015 |
| MO3-slc2a1b | N/A | Delcourt et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dystonia 9 | Alliance | Dystonia 9 | 601042 |
| glucose transporter type 1 deficiency syndrome 1 | Alliance | GLUT1 deficiency syndrome 1, infantile onset, severe | 606777 |
| glucose transporter type 1 deficiency syndrome 2 | Alliance | GLUT1 deficiency syndrome 2, childhood onset | 612126 |
| obsolete idiopathic generalized epilepsy 12 | Alliance | {Epilepsy, idiopathic generalized, susceptibility to, 12} | 614847 |
| Stomatin-deficient cryohydrocytosis with neurologic defects | 608885 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glucose transporter GLUT | Major facilitator, sugar transporter-like | Major facilitator superfamily domain | MFS transporter superfamily | Sugar/inositol transporter | Sugar transporter, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R0Q1 | InterPro | 489 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc2a1b-201
(1)
|
Ensembl | 1,823 nt | ||
| mRNA |
slc2a1b-202
(1)
|
Ensembl | 1,371 nt | ||
| mRNA |
slc2a1b-203
(1)
|
Ensembl | 1,392 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-85E16 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-92F12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002662528 (1) | 2317 nt | ||
| Genomic | GenBank:CR788236 (2) | 95897 nt | ||
| Polypeptide | UniProtKB:F1R0Q1 (1) | 489 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Méjécase, C., Nair, N., Sarkar, H., Soro-Barrio, P., Toms, M., Halliday, S., Linkens, K., Jaroszynska, N., Maurer, C., Owen, N., Moosajee, M. (2024) Oxidative Stress, Inflammation and Altered Glucose Metabolism Contribute to the Retinal Phenotype in the Choroideremia Zebrafish. Antioxidants (Basel, Switzerland). 13(12):
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
- Jia, P.P., Chandrajith, R., Junaid, M., Li, T.Y., Li, Y.Z., Wei, X.Y., Liu, L., Pei, D.S. (2023) Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Environmental pollution (Barking, Essex : 1987). 332:121967
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Nipu, N., Antomagesh, F., Faught, E., Vijayan, M.M. (2022) Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish. Scientific Reports. 12:15677
- Tabler, C.T., Lodd, E., Bennewitz, K., Middel, C.S., Erben, V., Ott, H., Poth, T., Fleming, T., Morgenstern, J., Hausser, I., Sticht, C., Poschet, G., Szendroedi, J., Nawroth, P.P., Kroll, J. (2022) Loss of glyoxalase 2 alters the glucose metabolism in zebrafish. Redox Biology. 59:102576102576
- Griffin, A., Carpenter, C., Liu, J., Paterno, R., Grone, B., Hamling, K., Moog, M., Dinday, M.T., Figueroa, F., Anvar, M., Ononuju, C., Qu, T., Baraban, S.C. (2021) Phenotypic analysis of catastrophic childhood epilepsy genes. Communications biology. 4:680
- Kang, T., Zhao, S., Shi, L., Li, J. (2021) Glucose metabolism is required for oocyte maturation of zebrafish. Biochemical and Biophysical Research Communications. 559:191-196
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