Gene
tdp1
- ID
- ZDB-GENE-090909-1
- Name
- tyrosyl-DNA phosphodiesterase 1
- Symbol
- tdp1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands. Involved in adult locomotory behavior. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in spinocerebellar ataxia with axonal neuropathy 1. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Zaksauskaite et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6467 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23033 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42901 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sh475 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| sh476 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| zdf45 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| zdf46 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia with axonal neuropathy 1 | Alliance | ?Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 | 607250 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR010347 | Tyrosyl-DNA phosphodiesterase I |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Tyrosyl-DNA phosphodiesterase I |
|---|---|---|---|
| UniProtKB:F8W5U2 | InterPro | 615 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-11L18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-104G13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_695082 (1) | 2319 nt | ||
| Genomic | GenBank:BX005004 (1) | 216131 nt | ||
| Polypeptide | UniProtKB:F8W5U2 (1) | 615 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Anticevic, I., Otten, C., Vinkovic, L., Jukic, L., Popovic, M. (2023) Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks in vivo. Open Biology. 13:230113230113
- Zhu, W., Shi, Y., Zhang, C., Peng, Y., Wan, Y., Xu, Y., Liu, X., Han, B., Zhao, S., Kuang, Y., Song, H., Qiao, J. (2023) In-frame deletion of SMC5 related with the phenotype of primordial dwarfism, chromosomal instability and insulin resistance. Clinical and translational medicine. 13:e1007e1007
- Zaksauskaite, R., Thomas, R.C., van Eeden, F., El-Khamisy, S.F. (2021) Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Science advances. 7(5):
- Zhang, L., Chen, C., Fu, J., Lilley, B., Berlinicke, C., Hansen, B., Ding, D., Wang, G., Wang, T., Shou, D., Ye, Y., Mulligan, T., Emmerich, K., Saxena, M.T., Hall, K.R., Sharrock, A.V., Brandon, C., Park, H., Kam, T.I., Dawson, V.L., Dawson, T.M., Shim, J.S., Hanes, J., Ji, H., Liu, J.O., Qian, J., Ackerley, D.F., Rohrer, B., Zack, D.J., Mumm, J.S. (2021) Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa. eLIFE. 10:
- Jing, C.B., Fu, C., Prutsch, N., Wang, M., He, S., Look, A.T. (2020) Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors. Leukemia. 34(11):2992-3006
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Akitake, C.M., Macurak, M., Halpern, M.E., and Goll, M.G. (2011) Transgenerational analysis of transcriptional silencing in zebrafish. Developmental Biology. 352(2):191-201
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