Gene
plekhg2
- ID
- ZDB-GENE-090819-1
- Name
- pleckstrin homology domain containing, family G (with RhoGef domain) member 2
- Symbol
- plekhg2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytosol. Orthologous to human PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wei et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8685 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukodystrophy and acquired microcephaly with or without dystonia | 616763 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dbl homology (DH) domain superfamily | Dbl homology domain | PH-like domain superfamily | PKHG1/2/3, pleckstrin homology (PH) domain | Pleckstrin homology domain | SOS1/NGEF-like, PH domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32T931 | InterPro | 553 | ||||||
| UniProtKB:A0AB32THR0 | InterPro | 553 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
plekhg2-201
(1)
|
Ensembl | 7,811 nt | ||
| mRNA |
plekhg2-202
(1)
|
Ensembl | 6,979 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-51K14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-244M22 | ||
| Contained in | BAC | DKEY-29H23 | ||
| Contained in | BAC | DKEY-46I14 | ||
| Contained in | Fosmid | ZFOS-691D2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068213820 (1) | 2194 nt | ||
| Genomic | GenBank:BX005374 (1) | 204318 nt | ||
| Polypeptide | UniProtKB:A0AB32T931 (1) | 553 aa |
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Wei, S., Dai, M., Liu, Z., Ma, Y., Shang, H., Cao, Y., Wang, Q. (2017) The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Cell Research. 27(2):202-225
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