Gene
srebf1
- ID
- ZDB-GENE-090812-3
- Name
- sterol regulatory element binding transcription factor 1
- Symbol
- srebf1 Nomenclature History
- Previous Names
-
- SREBP1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including pancreas regeneration; regulation of bone development; and type B pancreatic cell development. Predicted to be located in ER to Golgi transport vesicle membrane; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be active in nucleus. Is expressed in female organism; intestine; liver; male organism; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in coronary artery disease; disease of metabolism; and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 67 figures from 59 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| biu101 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| nju226 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa18770 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33346 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3756 | Allele with one delins | Exon 2 | Unknown | CRISPR |
1 - 5 of 5
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
| UniProtKB:A6XLD8 | InterPro | 1105 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srebf1-201
(1)
|
Ensembl | 2,826 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
- Chen, Y., Zheng, K., Leng, Y., Zhang, Z., Li, X., Li, X., Ou, H., Wen, M., Qiu, F., Yu, H. (2025) Alleviating effect of Lactobacillus fermentum E15 on hyperlipidemia and hepatic lipid metabolism in zebrafish fed by a high-fat diet through the production of short-chain fatty acids. Frontiers in nutrition. 12:15229821522982
- Hu, M., Veldman, M.B. (2025) Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway. Molecular neurodegeneration. 20:2828
- Donaka, R., Zheng, H., Ackert-Bicknell, C.L., Karasik, D. (2024) Early life lipid overload in Native American Myopathy is phenocopied by stac3 knockout in zebrafish. Gene. 936:149123
- Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):
- Guggeri, L., Sosa-Redaelli, I., Cárdenas-Rodríguez, M., Alonso, M., González, G., Naya, H., Prieto-Echagüe, V., Lepanto, P., Badano, J.L. (2024) Follistatin like-1 (Fstl1) regulates adipose tissue development in zebrafish. Adipocyte. 13:24358622435862
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Lin, B., Wan, H., Yang, J., Yu, L., Zhou, H., Wan, H. (2024) Lipid regulation of protocatechualdehyde and hydroxysafflor yellow A via AMPK/SREBP2/PCSK9/LDLR signaling pathway in hyperlipidemic zebrafish. Heliyon. 10:e24908e24908
- Ulhaq, Z.S., Tse, W.K.F. (2024) PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease. Genes. 15(1):
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
1 - 10 of 173
Show