Gene
vap
- ID
- ZDB-GENE-090313-42
- Name
- vascular associated protein
- Symbol
- vap Nomenclature History
- Previous Names
-
- ns:073-h07-2 (1)
- si:ch211-14k19.6
- si:ch211-14k19.7
- si:ch211-14k19.8
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Acts upstream of or within angiogenesis; erythrocyte differentiation; and hemoglobin biosynthetic process. Located in membrane. Is expressed in several structures, including blood vasculature; hematopoietic system; lateral plate mesoderm; notochord; and tail bud.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kawahara et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vap | (2) | |
| CRISPR2-vap | (2) | |
| MO1-vap | N/A | Kawahara et al., 2012 |
| MO2-vap | N/A | Kawahara et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain |
|---|---|---|---|
| UniProtKB:A0A8M9PWZ2 | InterPro | 1196 | |
| UniProtKB:A0A0R4IU71 | InterPro | 1203 | |
| UniProtKB:A0AB32TW59 | InterPro | 1203 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-14k19.8-201
(1)
|
Ensembl | 609 nt | ||
| mRNA |
si:ch211-14k19.8-202
(1)
|
Ensembl | 3,789 nt | ||
| mRNA |
vap-201
(1)
|
Ensembl | 377 nt | ||
| mRNA |
vap-202
(1)
|
Ensembl | 540 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-14K19 | ZFIN Curated Data | |
| Encodes | EST | affy:dr.19496.1.a1_at | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003197620 (1) | 3915 nt | ||
| Genomic | GenBank:BX004779 (1) | 196036 nt | ||
| Polypeptide | UniProtKB:A0A0R4IU71 (1) | 1203 aa |
No data available
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107
- Kawahara, A., Endo, S., and Dawid, I.B. (2012) Vap (Vascular Associated Protein): A novel factor involved in erythropoiesis and angiogenesis. Biochemical and Biophysical Research Communications. 421(2):367-374
- Weber, G.J., Choe, S.E., Dooley, K.A., Paffett-Lugassy, N.N., Zhou, Y., and Zon, L.I. (2005) Mutant-specific gene programs in the zebrafish. Blood. 106(2):521-530
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