Gene
mctp1b
- ID
- ZDB-GENE-090313-382
- Name
- multiple C2 domains, transmembrane 1b
- Symbol
- mctp1b Nomenclature History
- Previous Names
-
- si:dkeyp-33d3.1
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in membrane. Predicted to be active in synaptic vesicle membrane. Is expressed in several structures, including central nervous system; embryonic structure; notochord; optic cup; and pronephric duct. Orthologous to human MCTP1 (multiple C2 and transmembrane domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Espino-Saldaña et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | Multiple C2 domain and Transmembrane region Proteins, C-terminal |
---|---|---|---|---|---|
UniProtKB:A0A8M1RRA4 | InterPro | 859 | |||
UniProtKB:A0A0R4IF57 | InterPro | 858 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
mctp1b-201
(1)
|
Ensembl | 5,721 nt | ||
mRNA |
mctp1b-202
(1)
|
Ensembl | 280 nt | ||
mRNA |
mctp1b-203
(1)
|
Ensembl | 5,399 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEYP-33D3 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_002663670 (1) | |||
Genomic | GenBank:CT583727 (1) | 165752 nt | ||
Polypeptide | UniProtKB:A0A8M1RRA4 (1) | 859 aa |
- Espino-Saldaña, A.E., Durán-Ríos, K., Olivares-Hernandez, E., Rodríguez-Ortiz, R., Arellano-Carbajal, F., Martínez-Torres, A. (2020) Temporal and spatial expression of zebrafish mctp genes and evaluation of frameshift alleles of mctp2b. Gene. 738:144371
- van Leeuwen, L.M., Evans, R.J., Jim, K.K., Verboom, T., Fang, X., Bojarczuk, A., Malicki, J., Johnston, S.A., van der Sar, A.M. (2018) A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5.. Biology Open. 7(2)
- Gurung, R., Ono, Y., Baxendale, S., Lee, S.L., Moore, S., Calvert, M., Ingham, P.W. (2017) The Zebrafish frozen Mutant Is a Model for Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Genetics. 205(2):725-735
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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