Gene
kcnk1b
- ID
- ZDB-GENE-090312-78
- Name
- potassium channel, subfamily K, member 1b
- Symbol
- kcnk1b Nomenclature History
- Previous Names
-
- si:ch211-67f13.6
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables potassium channel activity. Acts upstream of or within heart process. Predicted to be located in several cellular components, including apical plasma membrane; perikaryon; and recycling endosome. Predicted to be active in plasma membrane. Is expressed in brain and heart. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Christensen et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Christensen et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la027448Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa42252 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-kcnk1b | N/A | Christensen et al., 2016 |
MO2-kcnk1b | N/A | Christensen et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR013099 | Potassium channel domain |
Family | IPR001779 | Two pore domain potassium channel, TWIK-1 |
Family | IPR003092 | Two pore domain potassium channel, TASK family |
Family | IPR003280 | Two pore domain potassium channel |
Family | IPR005408 | Two pore domain potassium channel, TWIK family |
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Domain Details Per Protein
Protein | Additional Resources | Length | Potassium channel domain | Two pore domain potassium channel | Two pore domain potassium channel, TASK family | Two pore domain potassium channel, TWIK-1 | Two pore domain potassium channel, TWIK family |
---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IHS3 | InterPro | 176 | |||||
UniProtKB:B8A573 | InterPro | 337 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
kcnk1b-201
(1)
|
Ensembl | 1,651 nt | ||
mRNA |
kcnk1b-202
(1)
|
Ensembl | 626 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-231I5 | ZFIN Curated Data | |
Contained in | BAC | CH211-67F13 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001145575 (1) | |||
Genomic | GenBank:BX510990 (1) | 210138 nt | ||
Polypeptide | UniProtKB:B8A573 (1) | 337 aa |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Skarsfeldt, M.A., Bomholtz, S.H., Lundegaard, P.R., Lopez-Izquierdo, A., Tristani-Firouzi, M., Bentzen, B.H. (2018) Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization.. Acta physiologica (Oxford, England). 223(3):e13049
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Christensen, A.H., Chatelain, F.C., Huttner, I.G., Olesen, M.S., Soka, M., Feliciangeli, S., Horvat, C., Santiago, C.F., Vandenberg, J.I., Schmitt, N., Olesen, S.P., Lesage, F., Fatkin, D. (2016) The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size. Journal of Molecular and Cellular Cardiology. 97:24-35
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gierten, J., Hassel, D., Schweizer, P.A., Becker, R., Katus, H.A., and Thomas, D. (2012) Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels. Biomembranes. 1818(1):33-41
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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