Gene

arfgef2

ID
ZDB-GENE-090312-50
Name
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Symbol
arfgef2 Nomenclature History
Previous Names
  • si:dkey-192i18.4
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within with a positive effect on angioblast cell migration and cell migration involved in sprouting angiogenesis. Predicted to be located in Golgi apparatus; membrane; and perinuclear region of cytoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ARF guanine nucleotide exchange factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Lu et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Lu et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa9158Allele with one point mutationUnknownPremature StopENU
sa14736Allele with one point mutationUnknownSplice SiteENU
1 - 2 of 2
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-arfgef2N/ALu et al., 2019
1 - 1 of 1
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Human Disease
Associated With arfgef2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
periventricular nodular heterotopia Alliance Periventricular heterotopia with microcephaly 608097
1 - 1 of 1
Associated With arfgef2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000904 Sec7 domain
Domain IPR015403 Mon2/Sec7/BIG1-like, HDS
Domain IPR032629 Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain
Domain IPR032691 Mon2/Sec7/BIG1-like, HUS domain
Domain IPR046455 Sec7/BIG1-like, C-terminal domain
1 - 5 of 9 Show all
Domain Details Per Protein
Protein Additional Resources Length Armadillo-like helical Armadillo-type fold Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain Mon2/Sec7/BIG1-like, HDS Mon2/Sec7/BIG1-like, HUS domain Sec7/BIG1-like, C-terminal domain Sec7, C-terminal domain superfamily Sec7 domain Sec7 domain superfamily
UniProtKB:E7FCG1 InterPro 1846
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 23
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA arfgef2-201 (1) Ensembl 5,541 nt
mRNA arfgef2-202 (1) Ensembl 5,909 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-192I18ZFIN Curated Data
1 - 1 of 1
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanARFGEF220
Amino acid sequence comparison (1)
Phylogenetic tree (1)
MouseArfgef22
Amino acid sequence comparison (1)
Phylogenetic tree (1)
Citations