Gene
arfgef2
- ID
- ZDB-GENE-090312-50
- Name
- ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
- Symbol
- arfgef2 Nomenclature History
- Previous Names
-
- si:dkey-192i18.4
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within with a positive effect on angioblast cell migration and cell migration involved in sprouting angiogenesis. Predicted to be located in Golgi apparatus; membrane; and perinuclear region of cytoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ARF guanine nucleotide exchange factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Lu et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Lu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
periventricular nodular heterotopia | Alliance | Periventricular heterotopia with microcephaly | 608097 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain | Mon2/Sec7/BIG1-like, HDS | Mon2/Sec7/BIG1-like, HUS domain | Sec7/BIG1-like, C-terminal domain | Sec7, C-terminal domain superfamily | Sec7 domain | Sec7 domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7FCG1 | InterPro | 1846 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
arfgef2-201
(1)
|
Ensembl | 5,541 nt | ||
mRNA |
arfgef2-202
(1)
|
Ensembl | 5,909 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-192I18 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_002666467 (1) | |||
Genomic | GenBank:CR788311 (1) | 147664 nt | ||
Polypeptide | UniProtKB:E7FCG1 (1) | 1846 aa |
- Lu, F.I., Wang, Y.T., Wang, Y.S., Wu, C.Y., Li, C.C. (2019) Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(9):9959-9973
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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