Gene
camk2b2
- ID
- ZDB-GENE-090312-34
- Name
- calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
- Symbol
- camk2b2 Nomenclature History
- Previous Names
-
- si:dkey-259k14.5
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables calcium/calmodulin-dependent protein kinase activity. Acts upstream of or within embryonic pectoral fin morphogenesis; heart jogging; and protein autophosphorylation. Predicted to be located in organelle. Is expressed in brain; pectoral fin; pericardial region; somite; and tail bud.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017603Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa41741 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 2 of 2
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-camk2b2 | N/A | Rothschild et al., 2009 |
| MO2-camk2b2 | N/A | (2) |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 54 | Alliance | Intellectual developmental disorder, autosomal dominant 54 | 617799 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR013543 | Calcium/calmodulin-dependent protein kinase II, association-domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR032710 | NTF2-like domain superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium/calmodulin-dependent protein kinase II, association-domain | NTF2-like domain superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QCS7 | InterPro | 476 | |||||
| UniProtKB:A0A8M9QHD1 | InterPro | 516 | |||||
| UniProtKB:A0A8M9QHD4 | InterPro | 501 | |||||
| UniProtKB:A0A8M9QLC5 | InterPro | 536 | |||||
| UniProtKB:A0A8M9QLC8 | InterPro | 521 |
1 - 5 of 15 Show all
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
camk2b-203
(1)
|
Ensembl | 1,281 nt | ||
| mRNA |
camk2b-204
(1)
|
Ensembl | 489 nt | ||
| mRNA |
camk2b2-201
(1)
|
Ensembl | 943 nt | ||
| mRNA |
camk2b2-202
(1)
|
Ensembl | 495 nt |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-229P19 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009305704 (1) | 1873 nt | ||
| Genomic | GenBank:CR383667 (1) | 121560 nt | ||
| Polypeptide | UniProtKB:A0A8M3AXB0 (1) | 537 aa |
- Rothschild, S.C., Ingram, S.R., Lu, F.I., Thisse, B., Thisse, C., Parkerson, J.A., Tombes, R.M. (2020) Genetic compensation of γ CaMKII, an evolutionarily conserved gene. Gene. 742:144567
- Gurung, R., Ono, Y., Baxendale, S., Lee, S.L., Moore, S., Calvert, M., Ingham, P.W. (2017) The Zebrafish frozen Mutant Is a Model for Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B. Genetics. 205(2):725-735
- Roy, B., Ferdous, J., Ali, D.W. (2015) NMDA receptors on zebrafish Mauthner cells require CaMKII-α for normal development. Developmental Neurobiology. 75(2):145-62
- Khodiyar, V.K., Howe, D., Talmud, P.J., Breckenridge, R., Lovering, R.C. (2013) From zebrafish heart jogging genes to mouse and human orthologs: using Gene Ontology to investigate mammalian heart development.. F1000 Research. 2:1-17
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Francescatto, L., Rothschild, S.C., Myers, A.L., and Tombes, R.M. (2010) The activation of membrane targeted CaMK-II in the zebrafish Kupffer's vesicle is required for left-right asymmetry. Development (Cambridge, England). 137(16):2753-2762
- Rothschild, S.C., Easley, C.A. 4th, Francescatto, L., Lister, J.A., Garrity, D.M., and Tombes, R.M. (2009) Tbx5-mediated expression of Ca(2+)/calmodulin-dependent protein kinase II is necessary for zebrafish cardiac and pectoral fin morphogenesis. Developmental Biology. 330(1):175-184
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
1 - 9 of 9
Show