Gene
rasa1b
- ID
- ZDB-GENE-090311-50
- Name
- RAS p21 protein activator (GTPase activating protein) 1b
- Symbol
- rasa1b Nomenclature History
- Previous Names
-
- si:dkey-169a9.2
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in regulation of intracellular signal transduction. Predicted to be located in cytoplasm. Is expressed in head. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kawasaki et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-rasa1b | Greysson-Wong et al., 2023 | |
MO1-rasa1b | N/A | Kawasaki et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | RasGAP, SH3 domain | Ras GTPase-activating domain | Ras GTPase-activating protein | Ras GTPase-activating protein 1, C-terminal SH2 domain | Ras GTPase-activating protein, conserved site | Rho GTPase activation protein | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:E7F372 | InterPro | 1032 | ||||||||||||||
UniProtKB:A0AB32TX64 | InterPro | 1037 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
rasa1b-201
(1)
|
Ensembl | 4,941 nt | ||
mRNA |
rasa1b-203
(1)
|
Ensembl | 3,616 nt | ||
mRNA |
rasa1b-204
(1)
|
Ensembl | 4,210 nt | ||
mRNA |
rasa1b-205
(1)
|
Ensembl | 4,066 nt | ||
ncRNA |
rasa1b-002
(1)
|
Ensembl | 717 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-169A9 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068224037 (1) | 4951 nt | ||
Genomic | GenBank:CU463258 (1) | 114523 nt | ||
Polypeptide | UniProtKB:A0AB32TX64 (1) | 1037 aa |
- Greysson-Wong, J., Rode, R., Ryu, J.R., Chan, J.L., Davari, P., Rinker, K.D., Childs, S.J. (2023) rasa1-related arteriovenous malformation is driven by aberrant venous signalling. Development (Cambridge, England). 150(18):
- Shin, M., Yin, H.M., Shih, Y.H., Nozaki, T., Portman, D., Toles, B., Kolb, A., Luk, K., Isogai, S., Ishida, K., Hanasaka, T., Parsons, M.J., Wolfe, S.A., Burns, C.E., Burns, C.G., Lawson, N.D. (2023) Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish. Developmental Cell. 58(22):2614-2626.e7
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Roberto, V.P., Tiago, D.M., Gautvik, K., Cancela, M.L. (2015) Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Gene. 566(1):54-62
- Kawasaki, J., Aegerter, S., Fevurly, R.D., Mammoto, A., Mammoto, T., Sahin, M., Mably, J.D., Fishman, S.J., Chan, J. (2014) RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J. Clin. Invest.. 124(6):2774-84
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