Gene

rasa1b

ID
ZDB-GENE-090311-50
Name
RAS p21 protein activator (GTPase activating protein) 1b
Symbol
rasa1b Nomenclature History
Previous Names
  • si:dkey-169a9.2
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of intracellular signal transduction. Predicted to be located in cytoplasm. Is expressed in head. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Kawasaki et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ca59Allele with one insertionUnknownUnknownCRISPR
sa34987Allele with one point mutationUnknownPremature StopENU
sa41739Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With rasa1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Basal cell carcinoma, somatic 605462
Capillary malformation-arteriovenous malformation 1 608354
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Associated With rasa1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023152 Ras GTPase-activating protein, conserved site
Domain IPR000008 C2 domain
Domain IPR000980 SH2 domain
Domain IPR001452 SH3 domain
Domain IPR001849 Pleckstrin homology domain
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Domain Details Per Protein
Protein Additional Resources Length C2 domain C2 domain superfamily PH-like domain superfamily Pleckstrin homology domain RasGAP, SH3 domain Ras GTPase-activating domain Ras GTPase-activating protein Ras GTPase-activating protein 1, C-terminal SH2 domain Ras GTPase-activating protein, conserved site Rho GTPase activation protein SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily
UniProtKB:E7F372 InterPro 1032
UniProtKB:A0AB32TX64 InterPro 1037
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 10
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA rasa1b-201 (1) Ensembl 4,941 nt
mRNA rasa1b-203 (1) Ensembl 3,616 nt
mRNA rasa1b-204 (1) Ensembl 4,210 nt
mRNA rasa1b-205 (1) Ensembl 4,066 nt
ncRNA rasa1b-002 (1) Ensembl 717 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-169A9ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanRASA15
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseRasa113
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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