Gene
ap2a1
- ID
- ZDB-GENE-090302-2
- Name
- adaptor related protein complex 2 subunit alpha 1
- Symbol
- ap2a1 Nomenclature History
- Previous Names
-
- fa95c07
- si:ch211-195b15.3
- wu:fa95c07 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable clathrin adaptor activity. Acts upstream of or within convergent extension involved in axis elongation; dorsal/ventral axis specification; and hematopoietic stem cell differentiation. Predicted to be located in clathrin-coated pit and plasma membrane. Predicted to be part of AP-2 adaptor complex. Used to study autism spectrum disorder. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1907 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9933 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20049 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20050 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20051 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa26091 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33213 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ap2a1 | N/A | (2) |
| MO2-ap2a1 | N/A | Han et al., 2016 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | ap2a1sa1907/sa1907 | standard conditions | Zúñiga Mouret et al., 2024 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| Domain | IPR003164 | Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain |
| Domain | IPR008152 | Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain |
| Family | IPR017104 | Adaptor protein complex AP-2, alpha subunit |
| Family | IPR050840 | Adaptor Complexes Large Subunit |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Adaptor Complexes Large Subunit | Adaptor protein complex AP-2, alpha subunit | Armadillo-like helical | Armadillo-type fold | Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain | Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain | Clathrin adaptor, appendage, Ig-like subdomain superfamily | Clathrin/coatomer adaptor, adaptin-like, N-terminal | Coatomer/calthrin adaptor appendage, C-terminal subdomain | TBP domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TH56 | InterPro | 980 | ||||||||||
| UniProtKB:A0AB32TH60 | InterPro | 959 | ||||||||||
| UniProtKB:A0AB32TJW0 | InterPro | 935 | ||||||||||
| UniProtKB:A0AB32TK65 | InterPro | 959 | ||||||||||
| UniProtKB:A0AB32TP30 | InterPro | 980 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195B15 | ZFIN Curated Data | |
| Encodes | EST | fa95c07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068219092 (1) | 5456 nt | ||
| Genomic | GenBank:CR936975 (1) | 121737 nt | ||
| Polypeptide | UniProtKB:A0AB32TH56 (1) | 980 aa |
- Comparative Orthology
- Alliance
- Muscò, A., Martini, D., Digregorio, M., Broccoli, V., Andreazzoli, M. (2024) Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development. Genes. 15(4):
- Zúñiga Mouret, R., Greenbaum, J.P., Doll, H.M., Brody, E.M., Iacobucci, E.L., Roland, N.C., Simamora, R.C., Ruiz, I., Seymour, R., Ludwick, L., Krawitz, J.A., Groneberg, A.H., Marques, J.C., Laborde, A., Rajan, G., Del Bene, F., Orger, M.B., Jain, R.A. (2024) The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows. iScience. 27:109455109455
- Ramesh, S.T., Navyasree, K.V., Sah, S., Ashok, A.B., Qathoon, N., Mohanty, S., Swain, R.K., Umasankar, P.K. (2021) BMP2K phosphorylates AP-2 and regulates clathrin-mediated endocytosis. Traffic (Copenhagen, Denmark). 22(11):377-396
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Han, T., Yang, C.S., Chang, K.Y., Zhang, D., Imam, F.B., Rana, T.M. (2016) Identification of novel genes and networks governing hematopoietic stem cell development. EMBO reports. 17(12):1814-1828
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Umasankar, P.K., Sanker, S., Thieman, J.R., Chakraborty, S., Wendland, B., Tsang, M., and Traub, L.M. (2012) Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nature cell biology. 14(5):488-501
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