Gene

frem1a

ID
ZDB-GENE-081119-1
Name
Fras1 related extracellular matrix 1a
Symbol
frem1a Nomenclature History
Previous Names
  • rfl (1)
  • rafels (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Acts upstream of or within fin morphogenesis. Predicted to be located in basement membrane and membrane. Is expressed in fin fold pectoral fin bud; median fin fold; pectoral fin; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With frem1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bifid nose with or without anorectal and renal anomalies 608980
Manitoba oculotrichoanal syndrome 248450
Trigonocephaly 2 614485
1 - 3 of 3
Associated With frem1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001304 C-type lectin-like
Domain IPR003644 Na-Ca exchanger/integrin-beta4
Domain IPR045658 FRAS1-related extracellular matrix protein, N-terminal domain
Family IPR051561 FRAS1-related extracellular matrix
Homologous_superfamily IPR016186 C-type lectin-like/link domain superfamily
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length CalX-like domain superfamily CSPG repeat C-type lectin fold C-type lectin-like C-type lectin-like/link domain superfamily FRAS1-related extracellular matrix FRAS1-related extracellular matrix protein, N-terminal domain Na-Ca exchanger/integrin-beta4
UniProtKB:D7PS89 InterPro 2167
UniProtKB:A0A8M1NUJ1 InterPro 2167
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA frem1a-201 (1)
Ensembl
Ensembl 7,217 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
No data available
Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:NM_001190308 (1)7934 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:LO018328 (1)32943 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A0A8M1NUJ1 (1)2167 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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