Gene
grk5l
- ID
- ZDB-GENE-081105-95
- Name
- G protein-coupled receptor kinase 5 like
- Symbol
- grk5l Nomenclature History
- Previous Names
-
- si:dkey-220o5.1
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Acts upstream of or within determination of left/right symmetry; negative regulation of TOR signaling; and regulation of cilium assembly. Located in plasma membrane. Is expressed in several structures, including notochord; otic placode; pronephros; spinal cord; and tail bud. Orthologous to human GRK5 (G protein-coupled receptor kinase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Burkhalter et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la026584Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la026585Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa12450 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18662 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa27261 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
sa41284 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-grk5l | N/A | (3) |
MO2-grk5l | N/A | Burkhalter et al., 2013 |
MO3-grk5l | N/A | Burkhalter et al., 2013 |
MO4-grk5l | N/A | Guo et al., 2019 |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | AGC-kinase, C-terminal | GPCR kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 2 | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1R6F6 | InterPro | 575 | |||||||||
UniProtKB:A0A8M2BEP6 | InterPro | 584 | |||||||||
UniProtKB:A0AB32TU55 | InterPro | 552 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-322G6 | ZFIN Curated Data | |
Contained in | BAC | DKEY-220O5 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068223220 (1) | 4289 nt | ||
Genomic | GenBank:CR931937 (1) | 156516 nt | ||
Polypeptide | UniProtKB:A0A8M2BEP6 (1) | 584 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | GRK5 | 10 | Amino acid sequence comparison (2) |
- Guo, H., Du, X., Zhang, Y., Wu, J., Wang, C., Li, M., Hua, X., Zhang, X.A., Yan, J. (2019) Specific miRNA-GPCR networks regulate Sox9a/Sox9b activities to promote gonadal rejuvenation in zebrafish. Stem cells (Dayton, Ohio). 37(9):1189-1199
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Lessel, D., Muhammad, T., Casar Tena, T., Moepps, B., Burkhalter, M.D., Hitz, M.P., Toka, O., Rentzsch, A., Schubert, S., Schalinski, A., Bauer, U.M., Kubisch, C., Ware, S.M., Philipp, M. (2016) The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5. Scientific Reports. 6:33231
- Zhao, Z., Lee, R.T., Pusapati, G.V., Iyu, A., Rohatgi, R., Ingham, P.W. (2016) An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO reports. 17(5):739-52
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Koltowska, K., Paterson, S., Bower, N.I., Baillie, G.J., Lagendijk, A.K., Astin, J.W., Chen, H., Francois, M., Crosier, P.S., Taft, R.J., Simons, C., Smith, K.A., Hogan, B.M. (2015) mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes & Development. 29:1618-30
- Burkhalter, M.D., Fralish, G.B., Premont, R.T., Caron, M.G., and Philipp, M. (2013) Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking. Cell Reports. 4(4):625-632
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Soderblom, E.J., Philipp, M., Thompson, J.W., Caron, M.G., and Moseley, M.A. (2011) Quantitative label-free phosphoproteomics strategy for multifaceted experimental designs. Analytical chemistry. 83(10):3758-3764
1 - 10 of 11
Show