Gene

grk5l

ID
ZDB-GENE-081105-95
Name
G protein-coupled receptor kinase 5 like
Symbol
grk5l Nomenclature History
Previous Names
  • si:dkey-220o5.1
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable protein kinase activity. Acts upstream of or within determination of left/right symmetry; negative regulation of TOR signaling; and regulation of cilium assembly. Located in plasma membrane. Is expressed in several structures, including notochord; otic placode; pronephros; spinal cord; and tail bud. Orthologous to human GRK5 (G protein-coupled receptor kinase 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Burkhalter et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la026584TgTransgenic insertionUnknownUnknownDNA
la026585TgTransgenic insertionUnknownUnknownDNA
sa12450Allele with one point mutationUnknownPremature StopENU
sa18662Allele with one point mutationUnknownPremature StopENU
sa27261Allele with one point mutationUnknownMissense, Splice SiteENU
sa41284Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With grk5l Human Ortholog
No data available
Associated With grk5l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR016137 RGS domain
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Domain Details Per Protein
Protein Additional Resources Length AGC-kinase, C-terminal GPCR kinase Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily RGS domain RGS domain superfamily RGS, subdomain 2 Serine/threonine-protein kinase, active site
UniProtKB:F1R6F6 InterPro 575
UniProtKB:A0A8M2BEP6 InterPro 584
UniProtKB:A0AB32TU55 InterPro 552
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA grk5l-201 (1) Ensembl 2,099 nt
mRNA grk5l-202 (1) Ensembl 1,050 nt
mRNA grk5l-203 (1) Ensembl 900 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-322G6ZFIN Curated Data
Contained inBACDKEY-220O5ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGRK510
Amino acid sequence comparison (2)
Citations
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