Gene
gna14a
- ID
- ZDB-GENE-081105-76
- Name
- guanine nucleotide binding protein (G protein), alpha 14a
- Symbol
- gna14a Nomenclature History
- Previous Names
-
- Galpha 14a (1)
- si:ch211-155h12.8
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in action potential; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and phospholipase C-activating dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in barbel; gill; lip; mouth; and taste bud. Orthologous to human GNA14 (G protein subunit alpha 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000654 | G-protein alpha subunit, group Q |
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | G-protein alpha subunit, group Q | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8RNG4 | InterPro | 354 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gna14a-201
(1)
|
Ensembl | 1,098 nt | ||
| mRNA |
gna14a-202
(1)
|
Ensembl | 1,065 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-53F16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-155H12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_678897 (1) | 1641 nt | ||
| Genomic | GenBank:BX005248 (1) | 185135 nt | ||
| Polypeptide | UniProtKB:A0A2R8RNG4 (1) | 354 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ohmoto, M., Okada, S., Nakamura, S., Abe, K., and Matsumoto, I. (2011) Mutually exclusive expression of Gαia and Gα14 reveals diversification of taste receptor cells in zebrafish. The Journal of comparative neurology. 519(8):1616-1629
- Oka, Y., and Korsching, S.I. (2011) Shared and Unique G Alpha Proteins in the Zebrafish Versus Mammalian Senses of Taste and Smell. Chemical senses. 36(4):357-365
- Oka, Y., Saraiva, L.R., Kwan, Y.Y., and Korsching, S.I. (2009) The fifth class of Gα proteins. Proceedings of the National Academy of Sciences of the United States of America. 106(5):1484-1489
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