Gene
fdft1
- ID
- ZDB-GENE-081104-242
- Name
- farnesyl-diphosphate farnesyltransferase 1
- Symbol
- fdft1 Nomenclature History
- Previous Names
-
- si:ch73-107c13.2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable squalene synthase [NAD(P)H] activity. Predicted to be involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Predicted to act upstream of or within lipid biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in brain. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028288Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6657 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37183 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Squalene synthase deficiency | 618156 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019845 | Squalene/phytoene synthase, conserved site |
| Domain | IPR033904 | Trans-isoprenyl diphosphate synthases, head-to-head |
| Family | IPR002060 | Squalene/phytoene synthase |
| Family | IPR006449 | Squalene synthase-like |
| Family | IPR044844 | Trans-isoprenyl diphosphate synthases, eukaryotic-type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Isoprenoid synthase domain superfamily | Squalene/phytoene synthase | Squalene/phytoene synthase, conserved site | Squalene synthase-like | Trans-isoprenyl diphosphate synthases, eukaryotic-type | Trans-isoprenyl diphosphate synthases, head-to-head |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IVV5 | InterPro | 418 | ||||||
| UniProtKB:A0A8M9PPK1 | InterPro | 447 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-107C13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001202525 (1) | 1392 nt | ||
| Genomic | GenBank:CU207296 (1) | 98771 nt | ||
| Polypeptide | UniProtKB:A0A8M9PPK1 (1) | 447 aa |
- Deng, R., Medico-Salsench, E., Nikoncuk, A., Ramakrishnan, R., Lanko, K., Kühn, N.A., van der Linde, H.C., Lor-Zade, S., Albuainain, F., Shi, Y., Yousefi, S., Capo, I., van den Herik, E.M., van Slegtenhorst, M., van Minkelen, R., Geeven, G., Mulder, M.T., Ruijter, G.J.G., Lütjohann, D., Jacobs, E.H., Houlden, H., Pagnamenta, A.T., Metcalfe, K., Jackson, A., Banka, S., De Simone, L., Schwaede, A., Kuntz, N., Palculict, T.B., Abbas, S., Umair, M., AlMuhaizea, M., Colak, D., AlQudairy, H., Alsagob, M., Pereira, C., Trunzo, R., Karageorgou, V., Bertoli-Avella, A.M., Bauer, P., Bouman, A., Hoefsloot, L.H., van Ham, T.J., Issa, M., Zaki, M.S., Gleeson, J.G., Willemsen, R., Kaya, N., Arold, S.T., Maroofian, R., Sanderson, L.E., Barakat, T.S. (2023) AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model. Acta Neuropathologica. 146(2):353-368
- McGruer, V., Tanabe, P., Vliet, S.M.F., Dasgupta, S., Qian, L., Volz, D.C., Schlenk, D. (2021) Effects of phenanthrene exposure on cholesterol homeostasis and cardiotoxicity in zebrafish embryos. Environmental toxicology and chemistry. 40(6):1586-1595
- Pang, S., Guo, M., Zhang, X., Yu, L., Zhang, Z., Huang, L., Gao, J., Li, X. (2019) Myclobutanil developmental toxicity, bioconcentration and sex specific response in cholesterol in zebrafish (Denio rerio). Chemosphere. 242:125209
- Mu, X., Liu, J., Yang, K., Huang, Y., Li, X., Yang, W., Qi, S., Tu, W., Shen, G., Li, Y. (2018) 0# Diesel water-accommodated fraction induced lipid homeostasis alteration in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 242:952-961
- DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imrie, D., Nayar, S., Baryshnikova, A., Milev, M.P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H.H., Lehrman, M.A., Sacher, M., Sadler, K.C. (2016) trappc11 is required for protein glycosylation in zebrafish and humans. Molecular biology of the cell. 27(8):1220-34
- Mu, X., Wang, K., Chai, T., Zhu, L., Yang, Y., Zhang, J., Pang, S., Wang, C., Li, X. (2015) Sex specific response in cholesterol level in zebrafish (Danio rerio) after long-term exposure of difenoconazole. Environmental pollution (Barking, Essex : 1987). 197:278-86
- Wang, Y., Lu, Y., Zhang, Y., Ning, Z., Li, Y., Zhao, Q., Lu, H., Huang, R., Xia, X., Feng, Q., Liang, X., Liu, K., Zhang, L., Lu, T., Huang, T., Fan, D., Weng, Q., Zhu, C., Lu, Y., Li, W., Wen, Z., Zhou, C., Tian, Q., Kang, X., Shi, M., Zhang, W., Jang, S., Du, F., He, S., Liao, L., Li, Y., Gui, B., He, H., Ning, Z., Yang, C., He, L., Luo, L., Yang, R., Luo, Q., Liu, X., Li, S., Huang, W., Xiao, L., Lin, H., Han, B., Zhu, Z. (2015) The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation. Nature Genetics. 47(6):625-31
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Cinaroglu, A., Gao, C., Imrie, D., and Sadler, K.C. (2011) Atf6 plays protective and pathologic roles in fatty liver disease due to endoplasmic reticulum stress. Hepatology (Baltimore, Md.). 54(2):495-508
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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